Social psychiatry and psychiatric epidemiology · 2023

The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case-control study.

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Sideli Lucia, Aas Monica, Quattrone Diego, La Barbera Daniele, La Cascia Caterina, Ferraro Laura, Alameda Luis, Velthorst Eva, Trotta Giulia, Tripoli Giada, Schimmenti Adriano, Fontana Andrea, Gayer-Anderson Charlotte, Stilo Simona, Seminerio Fabio, Sartorio Crocettarachele, Marrazzo Giovanna, Lasalvia Antonio, Tosato Sarah, Tarricone Ilaria, Berardi Domenico, D'Andrea Giuseppe, EU-GEI WP2 Group, Arango Celso, Arrojo Manuel, Bernardo Miguel, Bobes Julio, Sanjuán Julio, Santos Jose Luis, Menezes Paulo Rossi, Del-Ben Cristina Marta, Jongsma Hannah E, Jones Peter B, Kirkbride James B, Llorca Pierre-Michel, Tortelli Andrea, Pignon Baptiste, de Haan Lieuwe, Selten Jean-Paul, Van Os Jim, Rutten Bart P, Bentall Richard, Di Forti Marta, Murray Robin M, Morgan Craig, Fisher Helen L

Аннотация

This study investigated if the association between childhood maltreatment and cognition among psychosis patients and community controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755) and unaffected controls (N = 1219) from the EU-GEI study were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). Controlling for FH and SZ-PRS did not attenuate the association between childhood maltreatment and IQ in cases or controls. Findings suggest that these expressions of genetic liability cannot account for the lower levels of cognition found among adults maltreated in childhood.

Предметные рубрики MeSH

Adult Humans Child Case-Control Studies Psychotic Disorders Schizophrenia Cognition Child Abuse

The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case-control study.

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Аннотация

Предметные рубрики MeSH