Polygenic Scores and Onset of Major Mood or Psychotic Disorders Among Offspring of Affected Parents.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Zwicker Alyson, Fullerton Janice M, Mullins Niamh, Rice Frances, Hafeman Danella M, van Haren Neeltje E M, Setiaman Nikita, Merranko John A, Goldstein Benjamin I, Ferrera Alessandra G, Stapp Emma K, de la Serna Elena, Moreno Dolores, Sugranyes Gisela, Herrero Sergio Mas, Roberts Gloria, Toma Claudio, Schofield Peter R, Edenberg Howard J, Wilcox Holly C, McInnis Melvin G, Powell Victoria, Propper Lukas, Denovan-Wright Eileen, Rouleau Guy, Castro-Fornieles Josefina, Hillegers Manon H J, Birmaher Boris, Thapar Anita, Mitchell Philip B, Lewis Cathryn M, Alda Martin, Nurnberger John I, Uher Rudolf
Аннотация
METHODS: Eight cohorts were combined to create a sample of 1,884 participants ages 2-36 years, including 1,339 offspring of parents with mood or psychotic disorders, who were prospectively assessed with diagnostic interviews over an average of 5.1 years. PGSs were constructed for depression, bipolar disorder, anxiety, attention deficit hyperactivity disorder (ADHD), schizophrenia, neuroticism, subjective well-being, p factor, and height (as a negative control). Cox regression was used to test associations between PGSs, family history of major mental illness, and onsets of major mood and psychotic disorders.
RESULTS: There were 435 onsets of major mood and psychotic disorders across follow-up. PGSs for neuroticism (hazard ratio=1.23, 95% CI=1.12-1.36), schizophrenia (hazard ratio=1.15, 95% CI=1.04-1.26), depression (hazard ratio=1.11, 95% CI=1.01-1.22), ADHD (hazard ratio=1.10, 95% CI=1.00-1.21), subjective well-being (hazard ratio=0.90, 95% CI=0.82-0.99), and p factor (hazard ratio=1.14, 95% CI=1.04-1.26) were associated with onsets. After controlling for family history, neuroticism PGS remained significantly positively associated (hazard ratio=1.19, 95% CI=1.08-1.31) and subjective well-being PGS remained significantly negatively associated (hazard ratio=0.89, 95% CI=0.81-0.98) with onsets.
CONCLUSIONS: Neuroticism and subjective well-being PGSs capture risk of major mood and psychotic disorders that is independent of family history, whereas PGSs for psychiatric illness provide limited predictive power when family history is known. Neuroticism and subjective well-being PGSs may complement family history in the early identification of persons at elevated risk.