Acute Severe Ulcerative Colitis Patients From Asia Have Lower Colectomy Risk Than Patients From Australasia.
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Fernandes Richard Gareth, Kim Dong Hyun, Ruddick-Collins Leonie, Vasudevan Abhinav, Brownson Anthony Robert, Ngoi Benjamin, Lin Chun-Chi, Haifer Craig, Kim Dae Sung, Swe Ei, Wright Emily Kate, Song Eun Mi, Mahy Gillian, Moore Gregory Thomas, Lee Hyun Seok, Kim Hyun Soo, Zhang Jennifer, Yan Mak Joyce Wing, Lee Jun, Lynch Kate, Gazelakis Kathryn, Rice Katie, Kim Kyeong Ok, Liu Jing, Lilian Bracken Lucy Mary, Garg Mayur, Schultz Michael, Clark Nicholas, Cao Qian, Gilmore Robert, Park Sang Hyoung, Kim Seong-Jung, Sagami Shintaro, Wei Shu-Chen, Kashkooli Soleiman, Schildkraut Tamar, Lin Wei-Chen, Hsu Wen-Hung, Lee Yoo Jin, Kim Eun Soo, Begun Jakob, Kobayashi Taku, An Yoon-Kyo
Аннотация
METHODS: This was a multinational, multicenter retrospective cohort study of consecutive patients hospitalized with ASUC meeting Truelove and Witts' criteria from January 2015 to December 2020, across 14 hospitals in 4 Asian countries and 9 ANZ hospitals.
RESULTS: A total of 861 patients were included, with 430 from Asia and 431 from ANZ. Baseline characteristics in the Asian and ANZ cohorts differed significantly, most notably with the Asian cohort having a lower proportion with an IBD family history (P < .001), more extensive disease at diagnosis (P < .001), and worse endoscopic severity (P < .001). At admission, significantly less Asian patients were currently taking corticosteroids, thiopurines, and biologics, and less had previous exposure to biologics (P < .005). More Asian patients were discharged on 5-aminosalicylates (P = .014), and fewer were prescribed corticosteroids (P = .049), thiopurines (P < .001), or advanced therapies (P < .001) on discharge, but more remained corticosteroid-dependent on follow-up (P < .029). The Asian cohort had lower rates of corticosteroid failure (21.5% vs 57.2%; P < .001), inpatient colectomy (2.8% vs 10.9%; P < .001), 1-year colectomy (4.7% vs 22.5%; P < .001), and readmission with ASUC within 12 months (9.3% vs 16.1%; P < .001), validated using a propensity score matched cohort.
CONCLUSIONS: The characteristics of patients with ASUC in Asia differ significantly from ANZ. Despite worse endoscopic severity and more extensive disease, the Asian ASUC cohort appears more corticosteroid-responsive with significantly lower colectomy rates and less requirement for advanced therapies.