Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology · 2002
[Pre-Core mutation of HBV among 26 families with history of chronic HBV infection in Shenyang].
Аннотация на английскомСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Li Zhiwei, Dou Xiaoguang, Liu Pei
Аннотация
OBJECTIVE: To investigate the Pre-Core mutations of HBV and clinical significance among families with history of chronic HBV infection.
METHODS: The G to A mutation at nucleotide 1896 in the pre C gene of HBV DNA was detected by PCR-RFLP.
RESULTS: The results showed that the mutation rate of G to A mutation at nucleotide 1896 in the pre C gene of HBV DNA was much higher in patients (56.3%) and their family members (40.5%) than in their spouses (25.0%). While the positive rate of anti-HBs in their spouses were 26.3%. On the other hand those mutations were much higher in chronic hepatitis B patients (52.4%) and HBV carriers (44.4%) than in chronic severe hepatitis B patients (20.0%).
CONCLUSIONS: The G to A mutation at nucleotide 1896 in the pre C gene of HBV DNA could be associated with persistent HBV infection.
METHODS: The G to A mutation at nucleotide 1896 in the pre C gene of HBV DNA was detected by PCR-RFLP.
RESULTS: The results showed that the mutation rate of G to A mutation at nucleotide 1896 in the pre C gene of HBV DNA was much higher in patients (56.3%) and their family members (40.5%) than in their spouses (25.0%). While the positive rate of anti-HBs in their spouses were 26.3%. On the other hand those mutations were much higher in chronic hepatitis B patients (52.4%) and HBV carriers (44.4%) than in chronic severe hepatitis B patients (20.0%).
CONCLUSIONS: The G to A mutation at nucleotide 1896 in the pre C gene of HBV DNA could be associated with persistent HBV infection.