Analysis of the Influence of Sex in 507 Patients With Moderate-to-Severe Atopic Dermatitis: Spanish Atopic Dermatitis Registry (BIOBADATOP).
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Navarro-Bielsa A, Gilaberte Y, Carrascosa J M, Ruiz-Villaverde R, Betlloch Mas I, Espasandín-Arias M, Lasheras-Pérez M A, González Quesada A, de la Cueva Dobao P, Chicharro P, Pereyra Rodríguez J J, Herrera Acosta E, Montero-Vilchez T, Elosua-González M, Curto-Barredo L, Munera-Campos M, Navarro-Triviño F J, Batalla A, Rodríguez Serna M, Castaño-González I, Alonso J, Arias-Santiago S, Roustan Gullón G, Bertolín-Colilla M, Ruiz Carrascosa J C, Couselo-Rodríguez C, Sanabria de la Torre R, Rosell-Díaz A, Giménez-Arnau A M, Martínez-Fernández S, García-Doval I, Descalzo-Gallego M Á, Silvestre Salvador J F
Аннотация
METHODS: We conducted a prospective observational study using data from the BIOBADATOP registry from March 2020 to February 2025. Demographic variables, severity scales (EASI, DLQI, POEM, pruritus VAS), comorbidities, treatments, and adverse events were collected. Statistical analysis was performed using Chi-square, Student's t-test, and Mann-Whitney tests, considering statistical significance at P<.05.
RESULTS: A total of 507 adult patients on systemic treatment were included (53.1% men, 46.9% women). Men showed greater disease severity according to EASI (21.7 vs 21.0) and higher serum IgE levels (1323 vs 638KU/L). Women reported greater pruritus intensity and worse POEM scores. Anxiety (26% vs 13%) and depression (15% vs 5%) were more frequent among women. No differences were observed in family history or atopic comorbidities. Similarly, no relevant differences were found in treatments received, treatment duration, or clinical response at 3, 6, and 12 months. However, women showed a higher rate of GI adverse events (97/1000 vs 19/1000 patient-years).
CONCLUSIONS: Clinical and comorbidity differences according to sex exist in moderate-to-severe AD. Men show greater disease severity and higher IgE levels, whereas women experience a greater perceived disease burden, pruritus, psychiatric comorbidities, and more GI adverse events. These findings support the need to consider sex as a factor in the evaluation and comprehensive management of AD.