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DOI 10.1073/pnas.1308632110

Медицинская библиотека · Proceedings of the National Academy of Sciences of the United States of America · 2013

Tracking the establishment of local endemic populations of an emergent enteric pathogen.

Holt Kathryn E, Thieu Nga Tran Vu, Thanh Duy Pham, Vinh Ha, Kim Dong Wook, Vu Tra My Phan, Campbell James I, Hoang Nguyen Van Minh, Vinh Nguyen Thanh, Minh Pham Van, Thuy Cao Thu, Nga Tran Thi Thu, Thompson Corinne, Dung Tran Thi Ngoc, Nhu Nguyen Thi Khanh, Vinh Phat Voong, Tuyet Pham Thi Ngoc, Phuc Hoang Le, Lien Nguyen Thi Nam, Phu Bui Duc, Ai Nguyen Thi Thuy, Tien Nguyen Manh, Dong Nguyen, Parry Christopher M, Hien Tran Tinh, Farrar Jeremy J, Parkhill Julian, Dougan Gordon, Thomson Nicholas R, Baker Stephen

СтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

Shigella sonnei is a human-adapted pathogen that is emerging globally as the dominant agent of bacterial dysentery. To investigate local establishment, we sequenced the genomes of 263 Vietnamese S. sonnei isolated over 15 y. Our data show that S. sonnei was introduced into Vietnam in the 1980s and has undergone localized clonal expansion, punctuated by genomic fixation events through periodic selective sweeps. We uncover geographical spread, spatially restricted frontier populations, and convergent evolution through local gene pool sampling. This work provides a unique, high-resolution insight into the microevolution of a pioneering human pathogen during its establishment in a new host population.

Для цитирования: Holt Kathryn E, Thieu Nga Tran Vu, Thanh Duy Pham, Vinh Ha, Kim Dong Wook, Vu Tra My Phan, Campbell James I, Hoang Nguyen Van Minh, Vinh Nguyen Thanh, Minh Pham Van, Thuy Cao Thu, Nga Tran Thi Thu, Thompson Corinne, Dung Tran Thi Ngoc, Nhu Nguyen Thi Khanh, Vinh Phat Voong, Tuyet Pham Thi Ngoc, Phuc Hoang Le, Lien Nguyen Thi Nam, Phu Bui Duc, Ai Nguyen Thi Thuy, Tien Nguyen Manh, Dong Nguyen, Parry Christopher M, Hien Tran Tinh, Farrar Jeremy J, Parkhill Julian, Dougan Gordon, Thomson Nicholas R, Baker Stephen. Tracking the establishment of local endemic populations of an emergent enteric pathogen.. Proceedings of the National Academy of Sciences of the United States of America. 2013. DOI: 10.1073/pnas.1308632110.

Предметные рубрики MeSH

Anti-Bacterial AgentsChildChild, PreschoolChromosomes, BacterialCiprofloxacinDysentery, BacillaryEndemic DiseasesEvolution, MolecularFluoroquinolonesGatifloxacinGenetic VariationGenome, BacterialGenomicsGeographyHumansInfantMolecular Sequence DataMutation RatePhylogenySequence Analysis, DNAShigella sonneiVietnam
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