Journal of the American Academy of Dermatology · 2023
Risk factors and outcomes of melanoma in children and adolescents: A retrospective multicenter study.
Многоцентровое исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Hawryluk Elena B, Moustafa Danna, Barry Kelly K, Bahrani Eman, Reusch Diana B, Brahmbhatt Meera, Chen Lily, Coughlin Carrie C, Gerami Pedram, Haddock Ellen, Hook Kristen, Humphrey Stephen R, Kao Pei-Chi, Kruse Lacey L, Lawley Leslie P, Mansour Danny, Marghoob Ashfaq A, Nguyen Julie, Phung Thuy L, Pope Elena, Raisanen Tom, Robinson Sarah, Rogers Tova, Schmidt Birgitta, Tran Gary, Travis Kate, Wolner Zachary, London Wendy B, Eichenfield Lawrence F, Huang Jennifer
Аннотация
BACKGROUND: Pediatric melanoma presents with distinct clinical features compared to adult disease.
OBJECTIVE: Characterize risk factors and negative outcomes in pediatric melanoma.
METHODS: Multicenter retrospective study of patients under 20 years diagnosed with melanoma between January 1, 1995 and June 30, 2015 from 11 academic medical centers.
RESULTS: Melanoma was diagnosed in 317 patients, 73% of whom were diagnosed in adolescence (age ≥11). Spitzoid (31%) and superficial spreading (26%) subtypes were most common and 11% of cases arose from congenital nevi. Sentinel lymph node biopsy was performed in 68% of cases and positive in 46%. Fatality was observed in 7% of cases. Adolescent patients with melanoma were more likely to have family history of melanoma (P = .046) compared to controls.
LIMITATIONS: Retrospective nature, cohort size, control selection, and potential referral bias.
CONCLUSION: Pediatric melanoma has diverse clinical presentations. Better understanding of these cases and outcomes may facilitate improved risk stratification of pediatric melanoma.
OBJECTIVE: Characterize risk factors and negative outcomes in pediatric melanoma.
METHODS: Multicenter retrospective study of patients under 20 years diagnosed with melanoma between January 1, 1995 and June 30, 2015 from 11 academic medical centers.
RESULTS: Melanoma was diagnosed in 317 patients, 73% of whom were diagnosed in adolescence (age ≥11). Spitzoid (31%) and superficial spreading (26%) subtypes were most common and 11% of cases arose from congenital nevi. Sentinel lymph node biopsy was performed in 68% of cases and positive in 46%. Fatality was observed in 7% of cases. Adolescent patients with melanoma were more likely to have family history of melanoma (P = .046) compared to controls.
LIMITATIONS: Retrospective nature, cohort size, control selection, and potential referral bias.
CONCLUSION: Pediatric melanoma has diverse clinical presentations. Better understanding of these cases and outcomes may facilitate improved risk stratification of pediatric melanoma.