Asian Pacific journal of allergy and immunology · 2016
Association of the chromosome 11p13.5 variant and atopic dermatitis with a family history of atopy in the Chinese Han population.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Cheng Fang, Zhao Jin-Hua, Tang Xian-Fa, Cheng Hui, Sheng Yu-Jun, Jiang Xiao-Yun, Fang Ling, Zhang Xiao-Guang, Zuo Xian-Bo, Zheng Xiao-Dong, Zhou Fu-Sheng, Tang Hua-Yang, Yang Sen, Xiao Feng-Li, Zhang Xue-Jun
Аннотация
BACKGROUND: Recent genome-wide association studies (GWAS) and a meta-analysis of GWAS for atopic dermatitis (AD) have identified some AD genetic loci in European and Japanese populations.
OBJECTIVE: To investigate whether some novel susceptibility loci are associated with AD in the Chinese Han population.
METHODS: We first selected eight novel susceptibility loci to replicate in 2,205 AD patients and 2,116 healthy controls using the Sequenom platform. Data were analyzed with PLINK 1.07 software.
RESULTS: We found that rs12634229 (3q13.2), rs7927894 (11p13.5) and rs878860 (11p15.4) showed a slight association with AD (P = 0.012, P = 0.033, P = 0.020, respectively); rs6780220 (3p21.33) was preferentially related to AD with keratosis pilaris, but did not reach the threshold of significance after correction. The frequency of rs7927894 allele T was significantly different between AD patients with a positive and negative family history of atopy.
CONCLUSION: The loci rs7927894 (11p13.5) are related to AD with a positive family history of atopy in Chinese Han population, providing novel insight into the genetic pathogenesis of AD.
OBJECTIVE: To investigate whether some novel susceptibility loci are associated with AD in the Chinese Han population.
METHODS: We first selected eight novel susceptibility loci to replicate in 2,205 AD patients and 2,116 healthy controls using the Sequenom platform. Data were analyzed with PLINK 1.07 software.
RESULTS: We found that rs12634229 (3q13.2), rs7927894 (11p13.5) and rs878860 (11p15.4) showed a slight association with AD (P = 0.012, P = 0.033, P = 0.020, respectively); rs6780220 (3p21.33) was preferentially related to AD with keratosis pilaris, but did not reach the threshold of significance after correction. The frequency of rs7927894 allele T was significantly different between AD patients with a positive and negative family history of atopy.
CONCLUSION: The loci rs7927894 (11p13.5) are related to AD with a positive family history of atopy in Chinese Han population, providing novel insight into the genetic pathogenesis of AD.
Предметные рубрики MeSH
AdolescentAdultAsian PeopleCase-Control StudiesChildChild, PreschoolChinaChromosomes, Human, Pair 11Dermatitis, AtopicFemaleGene FrequencyGenetic Association StudiesGenetic LociGenetic Predisposition to DiseaseHumansInfantInfant, NewbornMalePedigreePhenotypePolymorphism, Single NucleotideRisk FactorsSeverity of Illness IndexYoung Adult