Archives of otolaryngology--head & neck surgery · 2008
L-myc polymorphism in head and neck nonmelanoma skin and lower lip cancers.
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Gözü Aydin, Ergen Arzu, Dayicioglu Deniz, Yaylim Ilhan, Ozsoy Zafer, Isbir Turgay
Аннотация
OBJECTIVE: To evaluate the presence of L-myc gene variations as a genetic predisposition to head and neck nonmelanoma skin cancer (HNNMSC) and lower lip cancer (LLC).
DESIGN: A case-control study.
SETTING: An academic institute laboratory.
PARTICIPANTS: Twenty-four patients with HNNMSC and 27 with LLC were compared with 51 age- and sex-matched control subjects.
MAIN OUTCOME MEASURES: Polymerase chain reaction restriction fragment length polymorphism and agarose gel electrophoresis were used to determine the L-myc oncogene genotypes.
RESULTS: The presence of the LS genotype was found to be significantly increased in the study group, whereas the LL genotype was not detected. The S allele was also more frequent in the study group. The SS genotype was found to correlate with aggressive tumor behavior in patients with HNNMSC and a family history of cancer. Patients with LLC displayed significantly less of the SS genotype.
CONCLUSIONS: The L-myc gene polymorphism may help detect and prevent HNNMSC and LLC in susceptible individuals. It may also contribute to estimation of tumor behavior in patients with HNNMSC.
DESIGN: A case-control study.
SETTING: An academic institute laboratory.
PARTICIPANTS: Twenty-four patients with HNNMSC and 27 with LLC were compared with 51 age- and sex-matched control subjects.
MAIN OUTCOME MEASURES: Polymerase chain reaction restriction fragment length polymorphism and agarose gel electrophoresis were used to determine the L-myc oncogene genotypes.
RESULTS: The presence of the LS genotype was found to be significantly increased in the study group, whereas the LL genotype was not detected. The S allele was also more frequent in the study group. The SS genotype was found to correlate with aggressive tumor behavior in patients with HNNMSC and a family history of cancer. Patients with LLC displayed significantly less of the SS genotype.
CONCLUSIONS: The L-myc gene polymorphism may help detect and prevent HNNMSC and LLC in susceptible individuals. It may also contribute to estimation of tumor behavior in patients with HNNMSC.
Предметные рубрики MeSH
AdultAgedAged, 80 and overAllelesBasal Cell CarcinomaCarcinoma, Squamous CellCase-Control StudiesFemaleGenes, mycGenetic Carrier ScreeningGenetic Predisposition to DiseaseGenotypeHead and Neck NeoplasmsHomozygoteHumansLip NeoplasmsMaleMiddle AgedNeoplasm StagingPolymerase Chain ReactionPolymorphism, Restriction Fragment LengthPrognosisReference ValuesSkinSkin Neoplasms