Diagnosing renal failure due to diethylene glycol in children in a resource-constrained setting.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Akuse Rosamund Modupe, Eke Felicia Uchezuba, Ademola Adebowale Dele, Fajolu Iretiola Bamikeolu, Gbelee Henry Olusegun, Ihejiahi Ugochi, Bugaje Mairo Adamu, Anochie Ifoema Comfort, Asinobi Adanze Onyenonachi, Okafor Henrietta Uchenna, Adeleke Solomon Ibiyemi, Audu Lamidi Isah, Otuneye Adekunle, Disu Elizabeth, Idris Hafsat, Aikhonbare Henry, Yakubu Alhassan, Ogala William, Ogunrinde Olufemi, Wammanda Robinson, Orogade Adeola, Anyiam Jane, Eseigbe Edwin, Umar Lawal, Musa Hafsat, Onalo Richard, West Boma, Paul Nsirimobu, Lesi Folusho, Ladapo Taiwo, Boyede Ojombo, Okeowo Rahmon, Mustapha Akeem, Akinola Ibironke, Chima-Oduko Oma, Awobusuyi Olugbenga
Аннотация
METHODS: This was a multicenter study. Information was obtained from hospital records. Clinicopathological features of all children with AKI over a 6-month period were reviewed.
RESULTS: Sixty (50.4%) of 119 children ingested "My pikin" teething syrup. Compared to children who had not ingested it, they were significantly (p < 0.05) younger (11.95 vs. 31 months), more were anuric (98.3 vs. 74.6%), hypertensive (84 vs. 52%), had severe metabolic acidosis (46.7 vs. 20.5%), and died (96.6 vs. 71.2%). They developed increasing metabolic acidosis and multiorgan dysfunction despite peritoneal dialysis. Late presentation, financial difficulties, inadequate facilities for toxicology, and hemodialysis complicated management.
CONCLUSIONS: Identifying AKI associated with DEG is difficult. Detailed drug history, increasing metabolic acidosis, and multiorgan deterioration despite peritoneal dialysis should arouse suspicion. Simple diagnostic tests need to be developed and facilities for hemodialysis of infants and financial support provided. Recurrences can be prevented by creating awareness, improving manufacturing practices, field-testing of drugs, and international monitoring of pharmaceuticals imported for manufacture.