Marine drugs · 2017
Lactones from the Sponge-Derived Fungus Talaromyces rugulosus.
СтатьяНазвание и аннотация: Перевод в очереди
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Küppers Lisa, Ebrahim Weaam, El-Neketi Mona, Özkaya Ferhat C, Mándi Attila, Kurtán Tibor, Orfali Raha S, Müller Werner E G, Hartmann Rudolf, Lin Wenhan, Song Weiguo, Liu Zhen, Proksch Peter
Аннотация
The marine-derived fungus Talaromyces rugulosus isolated from the Mediterranean sponge Axinella cannabina and cultured on solid rice medium yielded seventeen lactone derivatives including five butenolides (1-5), seven (3S)-resorcylide derivatives (6-12), two butenolide-resorcylide dimers (13 and 14), and three dihydroisocoumarins (15-17). Among them, fourteen compounds (1-3, 6-16) are new natural products. The structures of the isolated compounds were elucidated by 1D and 2D NMR (Nuclear Magnetic Resonance) spectroscopy as well as by ESI-HRMS (ElectroSpray Ionization-High Resolution Mass Spectrometry). TDDFT-ECD (Time-Dependent Density Functional Theory-Electronic Circular Dichroism) calculations were performed to determine the absolute configurations of chiral compounds. The butenolide-resorcylide dimers talarodilactones A and B (13 and 14) exhibited potent cytotoxicity against the L5178Y murine lymphoma cell line with IC50 values of 3.9 and 1.3 µM, respectively.