Nature reviews. Clinical oncology · 2010
Interaction between capecitabine and brivudin in a patient with breast cancer.
Клинический случайСтатьяПоддержка исследования: вне правительства СШАОбзорНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Baena-Cañada José M, Martínez María J, García-Olmedo Obdulia, Jiménez-Bárcenas Reyes, Muriel-Cueto Pedro
Аннотация
BACKGROUND: A 66-year-old woman with metastatic mammary carcinoma, who was being treated with capecitabine, contracted a herpes zoster infection that was treated with the antiviral drug brivudin. A drug-drug interaction between brivudin and capecitabine caused medullar aplasia, serious toxic effects to the intestinal mucous membrane, hand-foot syndrome, onycholysis and dental pigmentation.
INVESTIGATIONS: Physical examination, blood analysis, blood cultures, chest X-ray, bone marrow aspiration and biopsy.
DIAGNOSIS: Serious adverse event secondary to inhibition of dihydropyrimidine dehydrogenase by a drug-drug interaction between capecitabine and brivudin.
MANAGEMENT: Intravenous hydration, imipenem, red blood cell and platelet transfusions, filgrastim, omeprazole, care of the mouth and feet, topical anesthetics, systemic analgesics and parenteral nutrition.
INVESTIGATIONS: Physical examination, blood analysis, blood cultures, chest X-ray, bone marrow aspiration and biopsy.
DIAGNOSIS: Serious adverse event secondary to inhibition of dihydropyrimidine dehydrogenase by a drug-drug interaction between capecitabine and brivudin.
MANAGEMENT: Intravenous hydration, imipenem, red blood cell and platelet transfusions, filgrastim, omeprazole, care of the mouth and feet, topical anesthetics, systemic analgesics and parenteral nutrition.
Предметные рубрики MeSH
AgedAnemia, AplasticAntimetabolites, AntineoplasticAntineoplastic Combined Chemotherapy ProtocolsAntiviral AgentsBreast NeoplasmsBromodeoxyuridineCapecitabineCarcinoma, Ductal, BreastCombined Modality TherapyDeoxycytidineDihydrouracil Dehydrogenase (NADP)Drug InteractionsFatal OutcomeFemaleFluorouracilHerpes ZosterHumansOnycholysisPalliative CarePeripheral Nervous System DiseasesSalvage TherapyStomatitisTooth Discoloration