The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2005
Cognitive, behavioral, and physiological changes in Alzheimer disease patients as a function of incontinence medications.
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Jewart Rita D, Green Joanne, Lu Ching-ju, Cellar Janet, Tune Larry E
Аннотация
OBJECTIVE: Authors evaluated the cognitive, neurophysiologic, and behavioral effects of incontinence medications in patients with Alzheimer disease (AD).
METHODS: Nine patients were evaluated, both on and off incontinence medication, for cognitive status, neuropsychiatric status, activities of daily living, and serum anticholinergic level. Caregivers were interviewed to evaluate behavioral status and caregiver burden.
RESULTS: Patients showed better performance on specific measures of cognition and behavior when not taking medication for incontinence. A significant, inverse correlation was found between mental status and anticholinergic level.
CONCLUSION: Although the sample size was small, the findings suggest that, in patients with AD, incontinence medications with anticholinergic properties may have detrimental effects on mental status and behavior.
METHODS: Nine patients were evaluated, both on and off incontinence medication, for cognitive status, neuropsychiatric status, activities of daily living, and serum anticholinergic level. Caregivers were interviewed to evaluate behavioral status and caregiver burden.
RESULTS: Patients showed better performance on specific measures of cognition and behavior when not taking medication for incontinence. A significant, inverse correlation was found between mental status and anticholinergic level.
CONCLUSION: Although the sample size was small, the findings suggest that, in patients with AD, incontinence medications with anticholinergic properties may have detrimental effects on mental status and behavior.
Предметные рубрики MeSH
Activities of Daily LivingAlzheimer DiseaseBenzhydryl CompoundsCaregiversCholinergic AntagonistsCognition DisordersCresolsCross-Over StudiesHumansMemory DisordersMental DisordersMuscarinic AntagonistsNeuropsychological TestsPhenylpropanolaminePsychometricsSingle-Blind MethodSurveys and QuestionnairesTolterodine TartrateUrinary IncontinenceWakefulness