Diabetes and the risk of non-Hodgkin's lymphoma and multiple myeloma in the European Prospective Investigation into Cancer and Nutrition.
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Khan Aneire E, Gallo Valentina, Linseisen Jakob, Kaaks Rudolf, Rohrmann Sabine, Raaschou-Nielsen Ole, Tjønneland Anne, Johnsen Hans E, Overvad Kim, Bergmann Manuela M, Boeing Heiner, Benetou Vasiliki, Psaltopoulou Theodora, Trichopoulou Antonia, Masala Giovanna, Mattiello Amalia, Grioni Sara, Tumino Rosario, Vermeulen Roel C H, Peeters Petra H M, Bueno-de-Mesquita H Bas, Ros Martine M, Lund Eiliv, Ardanaz Eva, Chirlaque María-Dolores, Jakszyn Paula, Larrañaga Nerea, Losada Adamina, Becker Nikolaus, Nieters Alexandra, Martínez-García Carmen, Agren Asa, Hallmans Göran, Berglund Göran, Manjer Jonas, Allen Naomi E, Key Timothy J, Bingham Sheila, Khaw Kay Tee, Slimani Nadia, Ferrari Pietro, Boffetta Paolo, Norat Teresa, Vineis Paolo, Riboli Elio, EPIC Group
Аннотация
DESIGN AND METHODS: In the European Prospective Investigation into Cancer and Nutrition (EPIC), 1,213 histologically confirmed incident cases of non-Hodgkin's lymphoma and multiple myeloma (594 men; 619 women) were identified during a follow-up of 8.5 years. Cox proportional hazard models were used to explore the association between self-reported diabetes, diagnosed after 30 years of age, and the risk of non-Hodgkin's lymphoma overall and multiple myeloma and various lymphoma subtypes.
RESULTS: We found no association between a personal history of diabetes and the risk of non-Hodgkin's lymphoma overall in men (HR: 1.28, 95% CI: 0.89-1.84), in women (HR: 0.71, 95% CI: 0.41- 1.24), or in men and women combined (HR: 1.09, 95% CI: 0.80-1.47). Among the B-non-Hodgkin's lymphoma subtypes, we observed a statistically significant increased risk of B-cell chronic lymphocytic leukemia (HR: 2.0, 95% CI: 1.04-3.86) in men, but not in women (HR: 1.07, 95% CI: 0.33-3.43).
CONCLUSIONS: This prospective study did not provide evidence for a role of self-reported diabetes in the etiology of non-Hodgkin's lymphoma overall or multiple myeloma. We found an increased risk of B-cell chronic lymphocytic leukemia among men with diabetes, but not among women. We hypothesize that diabetes may not play a causal role in the etiology of B-cell chronic lymphocytic leukemia, though the underlying pathogenic mechanisms of both disorders may include shared genetic, host and/or environmental susceptibility factors.