European journal of cancer (Oxford, England : 1990) · 2007
Hodgkin's lymphoma in children aged 5 years or less - the United Kingdom experience.
СтатьяНазвание и аннотация: Перевод в очереди
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Stoneham S, Ashley S, Pinkerton Ross, Hewitt Martin, Wallace W H B, Shankar A G, Children's Cancer and Leukaemia Group
Аннотация
PURPOSE: The aim of this study is to describe the natural history of Hodgkin's Lymphoma (HL) in a large unselected group of children aged 5 years or below at diagnosis, who were treated on a standard treatment programme in the United Kingdom between 1982 and 2000.
METHODS: Eighty-one unselected children with HL aged 5 years or under at diagnosis, treated on the United Kingdom Children's Cancer Study Group (UKCCSG) Hodgkin's trials HD1 (1982-1992) and HD2 (1992-2000), were included in the study.
RESULTS: Sixty-one patients (81%) presented with early stage disease (n=66). Fifty-three patients (65%) received combination chemotherapy, 28 (34%) received involved field radiotherapy (IF-RT) and 4 patients were treated with combined modality therapy. Eighteen children relapsed after primary therapy.
CONCLUSIONS: Children treated with IF-RT had a higher rate of primary treatment failures as well as increased late treatment-related morbidity.
METHODS: Eighty-one unselected children with HL aged 5 years or under at diagnosis, treated on the United Kingdom Children's Cancer Study Group (UKCCSG) Hodgkin's trials HD1 (1982-1992) and HD2 (1992-2000), were included in the study.
RESULTS: Sixty-one patients (81%) presented with early stage disease (n=66). Fifty-three patients (65%) received combination chemotherapy, 28 (34%) received involved field radiotherapy (IF-RT) and 4 patients were treated with combined modality therapy. Eighteen children relapsed after primary therapy.
CONCLUSIONS: Children treated with IF-RT had a higher rate of primary treatment failures as well as increased late treatment-related morbidity.