Emerging infectious diseases · 2022
National Monkeypox Surveillance, Central African Republic, 2001-2021.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
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Besombes Camille, Mbrenga Festus, Schaeffer Laura, Malaka Christian, Gonofio Ella, Landier Jordi, Vickos Ulrich, Konamna Xavier, Selekon Benjamin, Dankpea Joella Namsenei, Von Platen Cassandre, Houndjahoue Franck Gislain, Ouaïmon Daniel Sylver, Hassanin Alexandre, Berthet Nicolas, Manuguerra Jean-Claude, Gessain Antoine, Fontanet Arnaud, Nakouné-Yandoko Emmanuel
Аннотация
We analyzed monkeypox disease surveillance in Central African Republic (CAR) during 2001-2021. Surveillance data show 95 suspected outbreaks, 40 of which were confirmed as monkeypox, comprising 99 confirmed and 61 suspected monkeypox cases. After 2018, CAR's annual rate of confirmed outbreaks increased, and 65% of outbreaks occurred in 2 forested regions bordering the Democratic Republic of the Congo. The median patient age for confirmed cases was 15.5 years. The overall case-fatality ratio was 7.5% (12/160) for confirmed and suspected cases, 9.6% (8/83) for children <16 years of age. Decreasing cross-protective immunity from smallpox vaccination and recent ecologic alterations likely contribute to increased monkeypox outbreaks in Central Africa. High fatality rates associated with monkeypox virus clade I also are a local and international concern. Ongoing investigations of zoonotic sources and environmental changes that increase human exposure could inform practices to prevent monkeypox expansion into local communities and beyond endemic areas.