Performance and complications of lumbar puncture in memory clinics: Results of the multicenter lumbar puncture feasibility study.
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Duits Flora H, Martinez-Lage Pablo, Paquet Claire, Engelborghs Sebastiaan, Lleó Alberto, Hausner Lucrezia, Molinuevo José L, Stomrud Erik, Farotti Lucia, Ramakers Inez H G B, Tsolaki Magda, Skarsgård Constance, Åstrand Ragnar, Wallin Anders, Vyhnalek Martin, Holmber-Clausen Marie, Forlenza Orestes V, Ghezzi Laura, Ingelsson Martin, Hoff Erik I, Roks Gerwin, de Mendonça Alexandre, Papma Janne M, Izagirre Andrea, Taga Mariko, Struyfs Hanne, Alcolea Daniel A, Frölich Lutz, Balasa Mircea, Minthon Lennart, Twisk Jos W R, Persson Staffan, Zetterberg Henrik, van der Flier Wiesje M, Teunissen Charlotte E, Scheltens Philip, Blennow Kaj
Аннотация
METHODS: We prospectively enrolled 3868 patients (50% women, age 66 ± 11 years, mini mental state examination 25 ± 5) at 23 memory clinics. We used logistic regression analysis using generalized estimated equations to investigate risk factors for post-LP complications, such as typical postlumbar puncture headache (PLPH) and back pain.
RESULTS: A total of 1065 patients (31%) reported post-LP complaints; 589 patients (17%) reported back pain, 649 (19%) headache, of which 296 (9%) reported typical PLPH. Only few patients needed medical intervention: 11 (0.3%) received a blood patch, 23 (0.7%) were hospitalized. The most important risk factor for PLPH was medical history of headache. An atraumatic needle and age >65 years were preventive. Gender, rest after LP, or volume of cerebrospinal fluid had no effect.
DISCUSSIONS: The overall risk of complications is relatively low. If risk factors shown in this study are taken into account, LPs can be safely performed in memory clinics.