Physical comorbidities of older age bipolar disorder (OABD) patients: A global replication analysis of prevalence and sex differences.
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Teixeira Antonio L, Almeida Osvaldo P, Lavin Paola, Barbosa Izabela G, Alda Martin, Altinbas Kursat, Balanzá-Martínez Vicent, Briggs Farren B S, Calkin Cynthia, Chen Peijun, Dols Annemieke, Eyler Lisa T, Forester Brent P, Forlenza Orestes V, Gildengers Ariel G, Hajek Tomas, Haarman Benno, Korten Nicole, Jimenez Esther, Lafer Beny, Levin Jennifer B, Montejo Laura, Nunes Paula V, Olagunju Andrew T, Oluwaniyi Stephen, Oudega Mardien L, Patrick Regan E, Radua Joaquim, Rej Soham, Schouws Sigfried, Soares Jair C, Sutherland Ashley N, Vieta Eduard, Yala Joy, Sajatovic Martha
Аннотация
METHODS: OABD was defined as bipolar disorder among adults aged ≥50 years. Outcomes analyzed were the prevalence of diseases affecting the cardiovascular, respiratory, gastrointestinal, genitourinary, renal, musculoskeletal, and endocrine systems. The analysis used cross-sectional data of OABD participants (n = 878; mean age 60.9 ± 8.0 years, n = 496 (56%) women) from the collaborative Global Aging & Geriatric Experiments in Bipolar Disorder (GAGE-BD) dataset and NC participants recruited at the same sites (n = 355; mean age 64.4 ± 9.7 years, n = 215 (61%) women).
RESULTS: After controlling for sex, age, education, and smoking history, the OABD group had more cardiovascular (odds ratio [95% confidence interval]: 2.12 [1.38-3.30]), renal (5.97 [1.31-43.16]), musculoskeletal (2.09 [1.30-3.43]) and endocrine (1.90 [1.20-3.05]) diseases than NC. Women with OABD had more gastrointestinal (1.56 [0.99-2.49]), genitourinary (1.72 [1.02-2.92]), musculoskeletal (2.64 [1.66-4.37]) and endocrine (1.71 [1.08-2.73]) comorbidities than men with OABD, when age, education, smoking history, and study site were controlled.
CONCLUSIONS: This replication GAGE-BD study confirms previous findings indicating that OABD present more physical morbidities than matched comparison participants, and that this health burden is significantly greater among women.