Phytochemistry · 2018
Cytotoxic and other withanolides from aeroponically grown Physalis philadelphica.
СтатьяНазвание и аннотация: Перевод в очереди
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Xu Ya-Ming, Wijeratne E M Kithsiri, Brooks Alan D, Tewary Poonam, Xuan Li-Jiang, Wang Wen-Qiong, Sayers Thomas J, Gunatilaka A A Leslie
Аннотация
Eleven withanolides including six previously undescribed compounds, 16β-hydroxyixocarpanolide, 24,25-dihydroexodeconolide C, 16,17-dehydro-24-epi-dioscorolide A, 17-epi-philadelphicalactone A, 16-deoxyphiladelphicalactone C, and 4-deoxyixocarpalactone A were isolated from aeroponically grown Physalis philadelphica. Structures of these withanolides were elucidated by the analysis of their spectroscopic (HRMS, 1D and 2D NMR, ECD) data and comparison with published data for related withanolides. Cytotoxic activity of all isolated compounds was evaluated against a panel of five human tumor cell lines (LNCaP, ACHN, UO-31, M14 and SK-MEL-28), and normal (HFF) cells. Of these, 17-epi-philadelphicalactone A, withaphysacarpin, philadelphicalactone C, and ixocarpalactone A exhibited cytotoxicity against ACHN, UO-31, M14 and SK-MEL-28, but showed no toxicity to HFF cells.