Atherosclerosis · 2012
Evaluation of possible subclinical atherosclerosis in adolescents with a family history of premature atherosclerosis.
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Celik Atac, Ozcetin Mustafa, Celikyay Zekiye Ruken Yuksekkaya, Sogut Erkan, Yerli Yasemin, Kadi Hasan, Koc Fatih, Damar Ibrahim Halil, Ceyhan Koksal, Erkorkmaz Unal
Аннотация
OBJECTIVE: To evaluate possible subclinical atherosclerosis using biomarkers and ultrasound-guided methods in a group of adolescents having fathers with premature atherosclerosis.
METHODS: Thirty-three subjects whose fathers had a history of premature coronary artery disease and 30 counterparts whose fathers had no history of coronary artery disease were included in the study.
RESULTS: The homocysteine levels, high-sensitivity C-reactive protein levels, and cardiac chamber sizes and functions did not differ between the two groups. The carotid stiffness index β (CSI), the intima-media thickness (CIMT) and aortic pulse wave velocity (PWV) values were higher in the group with a family history of coronary artery disease, but only the difference in the CSI was statistically significant (CSI 3.07±1.33 vs 3.88±1.25, P=0.015; CIMT 0.53±0.09 mm vs 0.57±0.08 mm, P=0.068; PWV 3.49±0.53 m/s vs 3.78±0.63 m/s, P=0.053).
CONCLUSION: Among several markers of subclinical atherosclerosis, the CSI was significantly higher in adolescents who had a family history of premature atherosclerosis. The small sample size, the multifactorial nature of atherosclerosis or the insufficient power of these methods may explain these results.
METHODS: Thirty-three subjects whose fathers had a history of premature coronary artery disease and 30 counterparts whose fathers had no history of coronary artery disease were included in the study.
RESULTS: The homocysteine levels, high-sensitivity C-reactive protein levels, and cardiac chamber sizes and functions did not differ between the two groups. The carotid stiffness index β (CSI), the intima-media thickness (CIMT) and aortic pulse wave velocity (PWV) values were higher in the group with a family history of coronary artery disease, but only the difference in the CSI was statistically significant (CSI 3.07±1.33 vs 3.88±1.25, P=0.015; CIMT 0.53±0.09 mm vs 0.57±0.08 mm, P=0.068; PWV 3.49±0.53 m/s vs 3.78±0.63 m/s, P=0.053).
CONCLUSION: Among several markers of subclinical atherosclerosis, the CSI was significantly higher in adolescents who had a family history of premature atherosclerosis. The small sample size, the multifactorial nature of atherosclerosis or the insufficient power of these methods may explain these results.
Предметные рубрики MeSH
AdolescentAdultAge of OnsetAortaAsymptomatic DiseasesBiomarkersC-Reactive ProteinCarotid ArteriesCarotid Intima-Media ThicknessCase-Control StudiesCoronary Artery DiseaseEchocardiography, Doppler, PulsedElasticityFathersFemaleGenetic Predisposition to DiseaseHeredityHomocysteineHumansMalePedigreePhenotypePulsatile FlowRisk AssessmentRisk FactorsTurkey