Description of BCG and Tuberculosis Disease in a Cohort of 79 Patients with Chronic Granulomatous Disease.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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León-Lara Ximena, Pérez-Blanco Uriel, Yamazaki-Nakashimada Marco A, Bustamante-Ogando Juan Carlos, Aguilar-Gómez Nancy, Cristerna-Tarrasa Hernán, Staines-Boone Aidé-Tamara, Saucedo-Ramírez Omar J, Fregoso-Zuñiga Eunice, Macías-Robles Ana-Paola, Canseco-Raymundo María R, Venancio-Hernández Marco, Moctezuma-Trejo Cristina, Gámez-González Berenise, Zarate-Hernández Carmen, Ramírez-Rivera Roselia, Scheffler-Mendoza Selma, Jiménez-Polvo Nancy, Hernández-Nieto Leticia, Carmona-Vargas Jocelyn, García-Cruz María L, Zavaleta-Martínez Óscar, Román-Montes Carla M, Cervantes-Parra Victoria, González-Reynoso Anelena, Guzmán-Cotaya Rogelio, Espinosa-Rosales Francisco, Saltigeral-Simental Patricia, Espinosa-Padilla Sara, Blancas Galicia Lizbeth
Аннотация
METHODS: Patients with CGD who were evaluated at the Immunodeficiency Laboratory of the National Institute of Pediatrics between 2013 and 2024 were included. Medical records were reviewed to determine the clinical course and treatment of adverse reactions to BCG and TB disease.
RESULTS: A total of 79 patients with CGD were included in this study. Adverse reactions to BCG were reported in 55 (72%) of 76 patients who received the vaccine. Tuberculosis was diagnosed in 19 (24%) patients. Relapse was documented in three (10%) of 31 patients with BGC-osis and six (32%) of 19 patients with TB, despite antituberculosis treatment. There was no difference in the frequency of BCG and TB disease between patients with pathogenic variants of the X-linked CYBB gene versus recessive variants.
CONCLUSIONS: This report highlights the importance of considering TB in endemic areas and BCG complications in children with CGD to enable appropriate diagnostic and therapeutic approaches to improve prognosis and reduce the risk of relapse.