Proceedings. Biological sciences · 2010
Bacillus Calmette-Guérin vaccination reduces the severity and progression of tuberculosis in badgers.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Chambers Mark A, Rogers Fiona, Delahay Richard J, Lesellier Sandrine, Ashford Roland, Dalley Deanna, Gowtage Sonya, Davé Dipesh, Palmer Si, Brewer Jacky, Crawshaw Timothy, Clifton-Hadley Richard, Carter Steve, Cheeseman Chris, Hanks Chris, Murray Alistair, Palphramand Kate, Pietravalle Stéphane, Smith Graham C, Tomlinson Alexandra, Walker Neil J, Wilson Gavin J, Corner Leigh A L, Rushton Stephen P, Shirley Mark D F, Gettinby George, McDonald Robbie A, Hewinson R Glyn
Аннотация
Control of bovine tuberculosis (TB) in cattle has proven particularly challenging where reservoirs of infection exist in wildlife populations. In Britain and Ireland, control is hampered by a reservoir of infection in Eurasian badgers (Meles meles). Badger culling has positive and negative effects on bovine TB in cattle and is difficult, costly and controversial. Here we show that Bacillus Calmette-Guérin (BCG) vaccination of captive badgers reduced the progression, severity and excretion of Mycobacterium bovis infection after experimental challenge. In a clinical field study, BCG vaccination of free-living badgers reduced the incidence of positive serological test results by 73.8 per cent. In common with other species, BCG did not appear to prevent infection of badgers subjected to experimental challenge, but did significantly reduce the overall disease burden. BCG vaccination of badgers could comprise an important component of a comprehensive programme of measures to control bovine TB in cattle.