Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026
Natural history and clinical characteristics of fish-induced food protein-induced enterocolitis syndrome (FPIES) in Greek children.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Miliordos Konstantinos, Triga Maria, Tranou Magdalini-Konstantina, Anvari Sara, Trujillo Juan
Аннотация
BACKGROUND: Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy presenting in infancy with delayed gastrointestinal symptoms. Although cow's milk and soy are common triggers globally, fish has emerged as a significant culprit in Mediterranean regions.
OBJECTIVE: To describe the clinical profile, natural history, and tolerance development of fish-induced FPIES in a pediatric Greek population.
METHODS: A retrospective review was conducted on 96 children diagnosed with acute fish-induced FPIES at a tertiary pediatric allergy unit in Greece between October 2014 and June 2024. Demographic, clinical, and follow-up data were analyzed, including oral food challenge (OFC) outcomes and multivariable predictors of tolerance.
RESULTS: Median age at first reaction was 11 months, and diagnosis was confirmed by 2 years. Codfish was the most common offending fish and was used in all OFCs. During follow-up, 73% of patients developed tolerance at a median age of 5.5 years. The amount of fish protein tolerated during the OFC exceeded 3 g (median: 10 g). A higher number of FPIES episodes before diagnosis was associated with nonachievement of tolerance (P < .001). A subset of children (14%) reported mild delayed abdominal discomfort after reintroduction despite a negative OFC result, leading to partial avoidance. No IgE sensitization was observed. Atopic comorbidities, particularly allergic rhinitis, were common.
CONCLUSION: Fish-induced FPIES represents a clinically significant diagnosis among Greek children. Most patients develop tolerance in early childhood, although a subset experiences lingering gastrointestinal discomfort after reintroduction. These findings highlight the need for awareness, early diagnosis, and careful reintroduction strategies in the management of fish-FPIES.
OBJECTIVE: To describe the clinical profile, natural history, and tolerance development of fish-induced FPIES in a pediatric Greek population.
METHODS: A retrospective review was conducted on 96 children diagnosed with acute fish-induced FPIES at a tertiary pediatric allergy unit in Greece between October 2014 and June 2024. Demographic, clinical, and follow-up data were analyzed, including oral food challenge (OFC) outcomes and multivariable predictors of tolerance.
RESULTS: Median age at first reaction was 11 months, and diagnosis was confirmed by 2 years. Codfish was the most common offending fish and was used in all OFCs. During follow-up, 73% of patients developed tolerance at a median age of 5.5 years. The amount of fish protein tolerated during the OFC exceeded 3 g (median: 10 g). A higher number of FPIES episodes before diagnosis was associated with nonachievement of tolerance (P < .001). A subset of children (14%) reported mild delayed abdominal discomfort after reintroduction despite a negative OFC result, leading to partial avoidance. No IgE sensitization was observed. Atopic comorbidities, particularly allergic rhinitis, were common.
CONCLUSION: Fish-induced FPIES represents a clinically significant diagnosis among Greek children. Most patients develop tolerance in early childhood, although a subset experiences lingering gastrointestinal discomfort after reintroduction. These findings highlight the need for awareness, early diagnosis, and careful reintroduction strategies in the management of fish-FPIES.