Anticancer research · 2026
Prognostic Factors for Pulmonary Metastasectomy for Colorectal Cancer: A Propensity Score Matching Analysis.
СтатьяНазвание и аннотация: Перевод в очереди
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Okado Shoji, Nakamura Shota, Sugihara Minoru, Kinoshita Fumie, Imamura Yoshito, Nomata Yuji, Takenaka Hirofumi, Watanabe Hiroki, Kawasumi Yuta, Nakanishi Keita, Kadomatsu Yuka, Ueno Harushi, Kato Taketo, Mizuno Tetsuya, Taniguchi Tetsuo, Chen-Yoshikawa Toyofumi Fengshi
Аннотация
BACKGROUND/AIM: This study aimed to investigate prognostic factors in pulmonary metastasectomy for colorectal cancer (CRC), considering the location of the primary tumor.
PATIENTS AND METHODS: We collected information from patients who underwent pulmonary resection for CRC at two high-volume centers from January 2010 to December 2023. Using a multivariate Cox proportional hazards model, patient background factors that affected the prognosis after pulmonary metastasectomy were identified.
RESULTS: A total of 289 patients were included in the study. The multivariate analysis revealed the primary tumor site [hazard ratio (HR)=1.89, p=0.016], the maximum diameter of the pulmonary nodule (HR=1.76, p=0.016), and multiple metastases (HR=2.10, p<0.001) had significant prognostic impact on overall survival (OS). The multivariate analysis of disease-free survival (DFS) revealed smoking history (HR=1.58, p=0.039) and multiple metastases (HR=2.08, p<0.001) as significant prognostic factors. After 1:1 propensity score matching (PSM) of patients based on the number of metastatic tumors, two populations revealed a consistent trend with 5-year survival rates of 73.4% and 48.0% for single pulmonary and multiple metastases.
CONCLUSION: Multiple metastases significantly worsened both OS and DFS after pulmonary metastasectomy, and the similar trend was observed after PSM.
PATIENTS AND METHODS: We collected information from patients who underwent pulmonary resection for CRC at two high-volume centers from January 2010 to December 2023. Using a multivariate Cox proportional hazards model, patient background factors that affected the prognosis after pulmonary metastasectomy were identified.
RESULTS: A total of 289 patients were included in the study. The multivariate analysis revealed the primary tumor site [hazard ratio (HR)=1.89, p=0.016], the maximum diameter of the pulmonary nodule (HR=1.76, p=0.016), and multiple metastases (HR=2.10, p<0.001) had significant prognostic impact on overall survival (OS). The multivariate analysis of disease-free survival (DFS) revealed smoking history (HR=1.58, p=0.039) and multiple metastases (HR=2.08, p<0.001) as significant prognostic factors. After 1:1 propensity score matching (PSM) of patients based on the number of metastatic tumors, two populations revealed a consistent trend with 5-year survival rates of 73.4% and 48.0% for single pulmonary and multiple metastases.
CONCLUSION: Multiple metastases significantly worsened both OS and DFS after pulmonary metastasectomy, and the similar trend was observed after PSM.