Gan to kagaku ryoho. Cancer & chemotherapy · 2025
[A Case of Oligometastatic Recurrent Colorectal Liver Metastasis Effectively Treated with Stereotactic Body Radiation Therapy].
СтатьяКлинический случайАннотация на английскомНазвание и аннотация: Перевод в очереди
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Takei Nobutsugu, Seyama Yasuji, Okinaga Hiroko, Kurata Masanao, Nakano Daisuke, Shimizuguchi Takuya, Suzuki Mizuka, Horiguchi Shinichiro
Аннотация
BACKGROUND: Colorectal cancer liver metastasis(CRLM)is commonly managed with surgery or systemic chemotherapy. However, alternative treatments are needed for patients who are not candidates for these standard therapies. Stereotactic body radiation therapy (SBRT) has shown promising results in terms of local control.
CASE: A 78-year-old woman underwent low anterior resection for rectal cancer(cStage Ⅲc)followed by 3 hepatic resections for metachronous CRLM. Upon the fourth recurrence, surgery was deemed infeasible due to advanced age, the location of recurrence, and surgical history. Additionally, the patient declined systemic chemotherapy. After multidisciplinary discussion, SBRT(50 Gy in 5 fractions)was chosen as the treatment strategy.
RESULTS: The patient tolerated SBRT without adverse events. Post-treatment imaging revealed tumor regression, and serum tumor markers normalized within 4 months. There has been no recurrence to date. She has remained disease-free for 5 years after the initial rectal surgery and 3 years following SBRT.
CONCLUSION: SBRT may be a safe and effective alternative for patients with recurrent CRLM who are not candidates for surgery or chemotherapy.
CASE: A 78-year-old woman underwent low anterior resection for rectal cancer(cStage Ⅲc)followed by 3 hepatic resections for metachronous CRLM. Upon the fourth recurrence, surgery was deemed infeasible due to advanced age, the location of recurrence, and surgical history. Additionally, the patient declined systemic chemotherapy. After multidisciplinary discussion, SBRT(50 Gy in 5 fractions)was chosen as the treatment strategy.
RESULTS: The patient tolerated SBRT without adverse events. Post-treatment imaging revealed tumor regression, and serum tumor markers normalized within 4 months. There has been no recurrence to date. She has remained disease-free for 5 years after the initial rectal surgery and 3 years following SBRT.
CONCLUSION: SBRT may be a safe and effective alternative for patients with recurrent CRLM who are not candidates for surgery or chemotherapy.