Медицинская библиотека · Tropical medicine & international health : TM & IH · 2023

Low seroprotection against diphtheria and tetanus in Lao adolescents.

Vantava Sonephet, Hefele Lisa, Virachith Siriphone, Vannachone Souphaphone, Khounvisith Vilaysone, Nouanthong Phonethipsavanh, Hübschen Judith M, Sayasone Somphou, Black Antony P

СтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

OBJECTIVES

There is currently no booster diphtheria or tetanus vaccine for Lao children before adolescence, despite international recommendations. We investigated seroprotection against diphtheria and tetanus among Lao adolescents.

METHODS

Seven hundred seventy-nine serum samples were tested for anti-diphtheria and anti-tetanus antibodies.

RESULTS

Overall, 25.8% of the adolescents had antibody titers corresponding to protection against diphtheria and 30.9% to sufficient immunity against tetanus. Female participants >16 years were more likely to be protected against diphtheria (p < 0.001) and tetanus (p < 0.029).

CONCLUSION

Low protection against diphtheria and tetanus, possibly due to low vaccination coverage or antibody waning, suggests booster doses are warranted before adolescence.

Для цитирования: Vantava Sonephet, Hefele Lisa, Virachith Siriphone, Vannachone Souphaphone, Khounvisith Vilaysone, Nouanthong Phonethipsavanh, Hübschen Judith M, Sayasone Somphou, Black Antony P. Low seroprotection against diphtheria and tetanus in Lao adolescents.. Tropical medicine & international health : TM & IH. 2023. DOI: 10.1111/tmi.13882.

Предметные рубрики MeSH

Child Humans Female Adolescent Laos Antibodies, Bacterial Immunization, Secondary Tetanus Toxoid Tetanus Diphtheria

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