The Journal of pediatrics · 1996
Humoral immunity in steroid-dependent children with asthma and hypogammaglobulinemia.
СтатьяПоддержка службы здравоохранения СШАНазвание и аннотация: Перевод в очереди
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Lack G, Ochs H D, Gelfand E W
Аннотация
OBJECTIVE: To determine primary and secondary antibody responses in children with hypogammaglobulinemia attributed to corticosteroid use.
RESULTS: In seven patients with steroid-dependent asthma and significant hypogammaglobulinemia (IgG concentration, 275 to 443 mg/dl), antibody responses to protein and polysaccharide antigens were shown to be normal, as were primary and secondary responses to a neoantigen, bacteriophage phi X174.
CONCLUSIONS: Patients with asthma, and with hypogammaglobulinemia resulting from steroid therapy, have normal humoral immunity, and immunoglobulin replacement therapy is not indicated.
RESULTS: In seven patients with steroid-dependent asthma and significant hypogammaglobulinemia (IgG concentration, 275 to 443 mg/dl), antibody responses to protein and polysaccharide antigens were shown to be normal, as were primary and secondary responses to a neoantigen, bacteriophage phi X174.
CONCLUSIONS: Patients with asthma, and with hypogammaglobulinemia resulting from steroid therapy, have normal humoral immunity, and immunoglobulin replacement therapy is not indicated.
Предметные рубрики MeSH
AdolescentAgammaglobulinemiaAnti-Asthmatic AgentsAntibody FormationAsthmaBacterial VaccinesBacteriophage phi X 174ChildChild, PreschoolDiphtheria ToxoidDiphtheria-Tetanus VaccineHaemophilus VaccinesHumansImmunizationImmunoglobulin AImmunoglobulin GImmunoglobulin MPrednisoneStreptococcus pneumoniaeTetanus ToxoidVaccines, Combined