Human vaccines & immunotherapeutics · 2025
Umbrella review of the safety of Chikungunya vaccine platforms used in other vaccines.
СтатьяСистематический обзорПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Bardach Ariel, Brizuela Martin, Berrueta Mabel, Ciapponi Agustín, Sambade Juan M, Ballivian Jamile, Ortega Vanesa, Castellana Noelia, Comandé Daniel, Parker Edward P K, Kampmann Beate, Stegelmann Katharina, Xiong Xu, Stergachis Andy, Munoz Flor M, Buekens Pierre, Mazzoni Agustina
Аннотация
Chikungunya virus (CHIKV), transmitted through Aedes mosquitoes, is a significant global health concern. Various vaccine platforms have been explored to combat CHIKV, including formalin inactivation, live-attenuated strains, virus-like particles (VLPs), viral vectors, and mRNA technologies. This umbrella review synthesizes evidence on the safety profiles of vaccine platforms used in Chikungunya vaccines that have been applied in other vaccines, focusing on adverse events of special interest (AESI) in pregnant persons, children, and adolescents. A comprehensive overview of systematic reviews (SRs) was conducted. Results: Seven systematic reviews were included and complemented with primary studies. Vaccines like influenza, human papillomavirus (HPV), and COVID-19, which share platforms with Chikungunya vaccines, showed no significant increase in AESI. Moderate-to high-quality SRs supported favorable safety profiles. Vaccines sharing platforms with Chikungunya vaccines generally exhibit acceptable safety profiles in pregnant persons, children, and adolescents.