Clinics (Sao Paulo, Brazil) · 2025
Impaired cardiopulmonary functions in prepubertal patients with Kawasaki disease.
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Lu Yen-Sen, Huang I-Ching, Wu Yen-Hsien, Tuan Sheng-Hui, Liu Yi-Ching, Wang Yi-Cheng, Lo Shih-Hsing, Hsu Jong-Hau, Lin Ko-Long
Аннотация
OBJECTIVE: This study investigated the cardiopulmonary function of prepubertal patients with Kawasaki Disease (KD) and compared it with that of healthy controls.
STUDY DESIGN: Retrospective cohort study METHODS: Data were collected from two medical centers in Taiwan from January 2014 to December 2023. Patients aged 8 to 12 years with a KD history were recruited. All patients and controls (age-, sex-, and body mass index -matched) underwent Cardiopulmonary Exercise Test (CPET) and pulmonary function test.
RESULTS: A total of 117 KD patients (mean age 9.64 ± 1.66 years; 68 males (58.1 %); (Body Mass Index [BMI] 19.21 ± 4.20 kg/m2) and 121 controls (mean age 9.72 ± 1.66 years; 71 males (58.7 %); BMI 18.47 ± 3.30 kg/m2) were analyzed. The average time from illness onset to enrollment was 7.94 ± 2.84 years. No significant differences in demographic characteristics or pulmonary function were observed. However, the KD group exhibited lower aerobic capacity (24.32 ± 5.02 vs. 26.08 ± 4.89 mL/min/kg, p < 0.001) and peak exercise tolerance (35.43 ± 7.31 vs. 38.48 ± 6.24 mL/min/kg, p < 0.001) compared to controls. Furthermore, the KD group had lower cardiopulmonary function than the control group among males, whereas the difference in females did not reach statistical significance.
CONCLUSIONS: Prepubertal individuals with a KD history demonstrated lower aerobic capacity and peak exercise tolerance than healthy peers, particularly among males. Despite this, they can safely engage in moderate-to-vigorous physical activities, which are essential for maintaining cardiopulmonary health in later life. Encouraging regular exercise among these patients is crucial.
STUDY DESIGN: Retrospective cohort study METHODS: Data were collected from two medical centers in Taiwan from January 2014 to December 2023. Patients aged 8 to 12 years with a KD history were recruited. All patients and controls (age-, sex-, and body mass index -matched) underwent Cardiopulmonary Exercise Test (CPET) and pulmonary function test.
RESULTS: A total of 117 KD patients (mean age 9.64 ± 1.66 years; 68 males (58.1 %); (Body Mass Index [BMI] 19.21 ± 4.20 kg/m2) and 121 controls (mean age 9.72 ± 1.66 years; 71 males (58.7 %); BMI 18.47 ± 3.30 kg/m2) were analyzed. The average time from illness onset to enrollment was 7.94 ± 2.84 years. No significant differences in demographic characteristics or pulmonary function were observed. However, the KD group exhibited lower aerobic capacity (24.32 ± 5.02 vs. 26.08 ± 4.89 mL/min/kg, p < 0.001) and peak exercise tolerance (35.43 ± 7.31 vs. 38.48 ± 6.24 mL/min/kg, p < 0.001) compared to controls. Furthermore, the KD group had lower cardiopulmonary function than the control group among males, whereas the difference in females did not reach statistical significance.
CONCLUSIONS: Prepubertal individuals with a KD history demonstrated lower aerobic capacity and peak exercise tolerance than healthy peers, particularly among males. Despite this, they can safely engage in moderate-to-vigorous physical activities, which are essential for maintaining cardiopulmonary health in later life. Encouraging regular exercise among these patients is crucial.