BMJ (Clinical research ed.) · 1991
Allergy to penicillin: fable or fact?
СтатьяНазвание и аннотация: Перевод в очереди
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Surtees S J, Stockton M G, Gietzen T W
Аннотация
OBJECTIVE: To assess whether, on the basis of one blood test, penicillin allergy might be excluded sufficiently for general practitioners to give oral penicillin to patients claiming a history of penicillin allergy.
DESIGN: Prospective study of patients referred by general practitioners.
SETTING: Outpatient allergy clinic in a district general hospital.
PATIENTS: 175 referred patients who gave a history of immediate type reaction to penicillin, of whom 144 attended as requested and 132 completed the investigations.
MAIN OUTCOME MEASURES: History and examination, serum radioallergosorbent test to phenoxymethylpenicillin and benzylpenicillin, and oral challenge with penicillin.
RESULTS: Of 132 patients, four were confirmed to have penicillin allergy by the radioallergosorbent test and 128 had an oral penicillin challenge without ill effect.
CONCLUSIONS: Most patients who gave a history of penicillin allergy are not so allergic, and their actual allergic state should be substantiated whenever feasible. For patients reporting minor or vague reactions negative findings with a radioallergosorbent test to phenoxymethylpenicillin and benzylpenicillin provide sufficient evidence to give oral penicillin safely.
DESIGN: Prospective study of patients referred by general practitioners.
SETTING: Outpatient allergy clinic in a district general hospital.
PATIENTS: 175 referred patients who gave a history of immediate type reaction to penicillin, of whom 144 attended as requested and 132 completed the investigations.
MAIN OUTCOME MEASURES: History and examination, serum radioallergosorbent test to phenoxymethylpenicillin and benzylpenicillin, and oral challenge with penicillin.
RESULTS: Of 132 patients, four were confirmed to have penicillin allergy by the radioallergosorbent test and 128 had an oral penicillin challenge without ill effect.
CONCLUSIONS: Most patients who gave a history of penicillin allergy are not so allergic, and their actual allergic state should be substantiated whenever feasible. For patients reporting minor or vague reactions negative findings with a radioallergosorbent test to phenoxymethylpenicillin and benzylpenicillin provide sufficient evidence to give oral penicillin safely.