Aspirin intolerance and recurrent urticaria in normal adults and children. Epidemiology and review.

The frequency of aspirin intolerance by history in 2,592 normal individuals was 0.3%. Although the frequency of aspirin intolerance was similar in adults and children, the bronchospastic type predominated in adults, and only the urticarial type was found in normal children. The frequency of recurrent urticaria, regardless of etiology, was significantly greater in adults than in children (3.8% vs. 0.3, P less than 0.001). In adults the frequency of aspirin intolerance was over 20 times greater in individuals with recurrent urticaria than in normal individuals (6.5% vs. 0.3%, P less than 0.001).