Медицинская библиотека · Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 1992

Hepatic lesions caused by excretory and secretory products of Ascaris lumbricoides in golden hamster.

Mazumder D N, Santra A, Dutta G, Ghosh N, Chowdhury M K

СтатьяПоддержка исследования: вне правительства СШАПеревод пока не подготовлен

Аннотация

OBJECTIVE

To ascertain the role of excretory and secretory (ES) products of Ascaris lumbricoides in liver damage.

METHODS

The ES products of A lumbricoides were collected in vitro and their SDS-PAGE analysis was done. Feeding and subcutaneous injection of ES products were done in hamsters. Estimation of serum proteins, alkaline phosphatase and alanine aminotransferase and histology of liver were carried out. Control animal experiments were done concurrently.

RESULTS

The ES products of A lumbricoides contained several proteins ranging in molecular weight from 14 to 205 Kd. Prolonged feeding of ES products caused elevation of ALT and amyloid deposition in the liver, whereas short term feeding or subcutaneous challenge caused focal cell necrosis and granuloma formation in the liver.

CONCLUSION

ES products of A lumbricoides can produce liver damage.

Для цитирования: Mazumder D N, Santra A, Dutta G, Ghosh N, Chowdhury M K. Hepatic lesions caused by excretory and secretory products of Ascaris lumbricoides in golden hamster.. Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology. 1992.

Предметные рубрики MeSH

Amyloidosis Animals Antigens, Helminth Ascariasis Ascaris Cricetinae Electrophoresis, Polyacrylamide Gel Granuloma Liver Liver Diseases, Parasitic Male Mesocricetus

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