Clinical cancer research : an official journal of the American Association for Cancer Research · 2008
Dietary intake of lactose as a strong predictor for secretor status of nipple aspirate fluid in healthy premenopausal nonlactating women.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАПоддержка правительства СШАПоддержка службы здравоохранения СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Huang Yafei, Anderson Karl E, Nagamani Manubai, Grady James J, Lu Lee-Jane W
Аннотация
PURPOSE: Nipple aspirate fluid (NAF) is considered a potential source for discovering breast cancer biomarkers. However, the success rate of obtaining NAF was reported to vary from 48% to 77%, and mechanisms for its secretion are not fully understood. The purpose of this study was to investigate dietary, demographic, reproductive, hormonal, and anthropometric factors that are associated with the ability to obtain NAF by aspiration (secretor status) from premenopausal women.
STUDY DESIGN: NAF procedures were attempted for women who were 30 to 40 years old, not pregnant, not breast-feeding, and not taking contraceptive medications.
RESULTS: Compared with nonsecretors, secretors of NAF consumed significantly more dietary lactose (mainly from milk), were more likely to be parous, were older at first and last childbirth, breast-fed their babies for a longer period of time, and had an earlier menarche and lower plasma concentrations of 17beta-estradiol (P < 0.05). Using multivariate logistic regression models, higher dietary intake of lactose [odds ratio (OR), 2.7; 95% confidence interval (95% CI), 1.5-4.8], earlier menarche (OR, 0.8; 95% CI, 0.7-1.0), being parous (OR, 2.3; 95% CI, 1.0-5.6), and being older at first childbirth (OR, 1.5; 95% CI, 1.0-2.1) were found to be independent and positive predictors for being a secretor of NAF.
CONCLUSIONS: These findings suggest that dietary intake of lactose, a modifiable factor, may be used to change the NAF secretor status of women. This finding may facilitate the use of NAF as a diagnostic material for detecting breast diseases.
STUDY DESIGN: NAF procedures were attempted for women who were 30 to 40 years old, not pregnant, not breast-feeding, and not taking contraceptive medications.
RESULTS: Compared with nonsecretors, secretors of NAF consumed significantly more dietary lactose (mainly from milk), were more likely to be parous, were older at first and last childbirth, breast-fed their babies for a longer period of time, and had an earlier menarche and lower plasma concentrations of 17beta-estradiol (P < 0.05). Using multivariate logistic regression models, higher dietary intake of lactose [odds ratio (OR), 2.7; 95% confidence interval (95% CI), 1.5-4.8], earlier menarche (OR, 0.8; 95% CI, 0.7-1.0), being parous (OR, 2.3; 95% CI, 1.0-5.6), and being older at first childbirth (OR, 1.5; 95% CI, 1.0-2.1) were found to be independent and positive predictors for being a secretor of NAF.
CONCLUSIONS: These findings suggest that dietary intake of lactose, a modifiable factor, may be used to change the NAF secretor status of women. This finding may facilitate the use of NAF as a diagnostic material for detecting breast diseases.