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Войти в исследования Acta paediatrica (Oslo, Norway : 1992) · 2012
Immunity after (re)vaccination of paediatric patients following haematopoietic stem cell transplantation.
Клиническое исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Olkinuora Helena, Käyhty Helena, Davidkin Irja, Roivainen Merja, Olander Rose-Marie, Kantele Jussi M, Siitonen Sanna, Vettenranta Kim
Аннотация
AIMS: Loss of specific immunity follows allogeneic haematopoietic stem cell transplantation (HSCT) in the majority of cases. Responses to (re)vaccinations can be used as indicators of a functional immunological recovery.
METHODS: Twenty-three paediatric recipients of HSCT were enrolled in a single centre setting and responses to scheduled immunizations analysed.
RESULTS: Immunity to vaccine-preventable diseases was impaired post HSCT, but (re)vaccinations induced protective responses in 59-100%, depending on the vaccine, regardless of prior graft-versus-host disease (GVHD) history.
CONCLUSION: Despite the marked impact of moderate to severe chronic prior GVHD on both the qualitative and quantitative T-cell recovery post allogenic HSCT, most paediatric recipients of allogeneic stem cell grafts appear to attain protective antibody levels after immunization.
METHODS: Twenty-three paediatric recipients of HSCT were enrolled in a single centre setting and responses to scheduled immunizations analysed.
RESULTS: Immunity to vaccine-preventable diseases was impaired post HSCT, but (re)vaccinations induced protective responses in 59-100%, depending on the vaccine, regardless of prior graft-versus-host disease (GVHD) history.
CONCLUSION: Despite the marked impact of moderate to severe chronic prior GVHD on both the qualitative and quantitative T-cell recovery post allogenic HSCT, most paediatric recipients of allogeneic stem cell grafts appear to attain protective antibody levels after immunization.
Предметные рубрики MeSH
AdolescentAntibodies, BacterialAntibodies, ViralChildChild, PreschoolDiphtheria ToxinFlow CytometryGraft vs Host DiseaseHaemophilus influenzae type bHematopoietic Stem Cell TransplantationHumansMeasles virusPoliovirusPostoperative CareProspective StudiesStreptococcus pneumoniaeTetanus ToxinTransplantation ImmunologyVaccinationVaccinesYoung Adult