Designing and molecular docking analysis of newly acetazolamide derived compounds integrating 4-oxothiazolidine group as possible carbonic anhydrase deactivators.

OBJECTIVE

Aim: To investigate immunological markers that may be associated with measles viral infections in aborted women, specifically cytokines IL-10 and IL-17.

PATIENTS AND

METHODS

Materials and

Methods

From October 2024 to the end of December 2024, the study included 352 participants, comprising 176 females with a history of abortions and 176 females with normal pregnancies, who acted as a control group. Serum samples were analyzed for IL-10 and IL-17 using the enzyme-linked immunosorbent assay (ELISA) method.

RESULTS

Results

The serum level of IL-10 was significantly lower in women with abortion compared to the control group, with a median of 216.02 pg/ml versus 329.79 pg/ml, respectively (p<0.001). Similarly, the serum level of IL-17 was significantly higher in women with abortion compared to the control group, with a median of 85.24 pg/ml versus 51.76 pg/ml, respectively p<0.001).

CONCLUSION

Conclusions

The main clinical features of a viral infection, such as measles, during pregnancy are fever. Correlation of IL-10 and IL-17 to measles infection in the control group: Measles IgM and IgG showed no significant correlation to IL-10 and IL-17 (p>0.05). In the abortion group, measles IgM and IgG showed significant positive correlation to IL-10 and IL-17 p<0.001, finally, family history is a significant risk factor for abortion.