[Zhonghua yan ke za zhi] Chinese journal of ophthalmology · 1997
[FTRaman and FTIR spectroscopy in lens with senile cataract].
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Chen C, Su X, Zhang X
Аннотация
OBJECTIVE: In order to search for the main composition and conformational changes of lens proteins in senile cataract.
METHODS: We firstly used Fourier transform Raman and infrared (FTRaman and FTIR) spectroscopy and semi-quantitative method in the integral calculus of related peaks to determine the conformational changes of lens protein during opacification of varying grade.
RESULTS: The spectral features of lenses with grade III cataract were intermediate between human clear lenses (grade 0) and grade IV or grade V cataractous lenses. The spectral characteristics of lenses with grade IV were very similar to that with grade V lenses, and some peaks of them were not seen in human clear lenses. The two spectral analyses showed that some findings were identical and some findings were complementary.
CONCLUSION: The development of lens opacification is correlated not only with the relative contents of alpha-, beta-, gamma-crystallines in lens proteins but also with the various damaged SH, trp, phe, -CH2 in lens protein of senile cataract.
METHODS: We firstly used Fourier transform Raman and infrared (FTRaman and FTIR) spectroscopy and semi-quantitative method in the integral calculus of related peaks to determine the conformational changes of lens protein during opacification of varying grade.
RESULTS: The spectral features of lenses with grade III cataract were intermediate between human clear lenses (grade 0) and grade IV or grade V cataractous lenses. The spectral characteristics of lenses with grade IV were very similar to that with grade V lenses, and some peaks of them were not seen in human clear lenses. The two spectral analyses showed that some findings were identical and some findings were complementary.
CONCLUSION: The development of lens opacification is correlated not only with the relative contents of alpha-, beta-, gamma-crystallines in lens proteins but also with the various damaged SH, trp, phe, -CH2 in lens protein of senile cataract.