Digestive diseases and sciences · 2009
Ileal mucosal and fecal pancreatitis associated protein levels reflect severity of salmonella infection in rats.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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van Ampting Marleen T J, Rodenburg Wendy, Vink Carolien, Kramer Evelien, Schonewille Arjan J, Keijer Jaap, van der Meer Roelof, Bovee-Oudenhoven Ingeborg M J
Аннотация
BACKGROUND: Microbial infections induce ileal pancreatitis-associated protein/regenerating gene III (PAP/RegIII) mRNA expression. Despite increasing interest, little is known about the PAP/RegIII protein. Therefore, ileal mucosal PAP/RegIII protein expression, localization, and fecal excretion were studied in rats upon Salmonella infection.
RESULTS: Salmonella infection increased ileal mucosal PAP/RegIII protein levels in enterocytes located at the crypt-villus junction. Increased colonization and translocation of Salmonella was associated with higher ileal mucosal PAP/RegIII levels and secretion of this protein in feces.
CONCLUSIONS: PAP/RegIII protein is increased in enterocytes of the ileal mucosa during Salmonella infection and is associated with infection severity. PAP/RegIII is excreted in feces and might be used as a new and non-invasive infection marker.
RESULTS: Salmonella infection increased ileal mucosal PAP/RegIII protein levels in enterocytes located at the crypt-villus junction. Increased colonization and translocation of Salmonella was associated with higher ileal mucosal PAP/RegIII levels and secretion of this protein in feces.
CONCLUSIONS: PAP/RegIII protein is increased in enterocytes of the ileal mucosa during Salmonella infection and is associated with infection severity. PAP/RegIII is excreted in feces and might be used as a new and non-invasive infection marker.
Предметные рубрики MeSH
AnimalsAntigens, NeoplasmBacterial TranslocationBiomarkersBiomarkers, TumorCalcium, DietaryDisease Models, AnimalEatingEnterocytesFecesIleitisIleumIntestinal MucosaLectins, C-TypeMalePancreatitis-Associated ProteinsRNA, MessengerRatsRats, WistarSalmonella Infections, AnimalSalmonella enteritidisSeverity of Illness IndexTime Factors