Ear and hearing · 2019
High-Frequency Horizontal Semicircular Canal Function in Certain Menière's Disease.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Jerin Claudia, Maxwell Rebecca, Gürkov Robert
Аннотация
OBJECTIVES: To characterize video head impulse testing (vHIT) in definitive Menière's disease and to investigate the relationship between vHIT results and other audiovestibular function tests.
DESIGN: Fifty-four patients with certain Menière's disease, that is, patients with clinically definite Menière's disease and endolymphatic hydrops visualized by locally enhanced inner ear MR imaging, were recruited for this study. All patients underwent vHIT. The vestibular-ocular reflex gain at 60 ms and refixation saccades were the outcome parameters measured. Saccades were characterized by determining the saccade frequency, their mean latency, and their mean velocity.
RESULTS: Seven of 54 patients had bilateral normal vHITs. Clearly pathologically vHITs with decreased gain and refixation saccades were observed in further seven patients. The majority of patients exhibited vHITs with refixation saccades but normal gain. Saccades mostly occurred bilaterally. There was no correlation between vHIT gain or saccades and caloric irrigation, cervical vestibular evoked myogenic potential or audiometry for Menière's ears. Furthermore, vHIT gain or saccades correlated neither with age nor with the duration of the disease.
CONCLUSIONS: Pathological low vHIT gain values are rarely observed in patients with certain Menière's disease, while refixation saccades occur very frequently. In the majority of patients, saccades occur bilaterally. In Menière's disease, in contrast to vestibular neuritis, there is no compensatory decrease of saccade latency over time.
DESIGN: Fifty-four patients with certain Menière's disease, that is, patients with clinically definite Menière's disease and endolymphatic hydrops visualized by locally enhanced inner ear MR imaging, were recruited for this study. All patients underwent vHIT. The vestibular-ocular reflex gain at 60 ms and refixation saccades were the outcome parameters measured. Saccades were characterized by determining the saccade frequency, their mean latency, and their mean velocity.
RESULTS: Seven of 54 patients had bilateral normal vHITs. Clearly pathologically vHITs with decreased gain and refixation saccades were observed in further seven patients. The majority of patients exhibited vHITs with refixation saccades but normal gain. Saccades mostly occurred bilaterally. There was no correlation between vHIT gain or saccades and caloric irrigation, cervical vestibular evoked myogenic potential or audiometry for Menière's ears. Furthermore, vHIT gain or saccades correlated neither with age nor with the duration of the disease.
CONCLUSIONS: Pathological low vHIT gain values are rarely observed in patients with certain Menière's disease, while refixation saccades occur very frequently. In the majority of patients, saccades occur bilaterally. In Menière's disease, in contrast to vestibular neuritis, there is no compensatory decrease of saccade latency over time.