Pediatric blood & cancer · 2018
Venoocclusive disease due to chemotherapy for pediatric acute lymphoblastic leukemia is associated with increased levels of plasminogen-activator inhibitor-1.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Mauro Margherita, Saggiorato Graziella, Sartori Maria Teresa, Gallo Giuseppe, De Bortoli Massimiliano, Bonetti Elisa, Zaccaron Ada, Vitale Virginia, Balter Rita, Chinello Matteo, Cesaro Simone
Аннотация
We describe three cases of sinusoidal obstruction syndrome/venoocclusive disease (SOS) in pediatric patients with acute lymphoblastic leukemia (ALL). All three episodes occurred during or just after the induction or reinduction phase of treatment based on prednisone/dexamethasone, vincristine, daunorubicin, and pegylated-l-asparaginase. SOS episodes were categorized as mild/moderate and resolved in 7, 10, and 16 days using supportive measures or defibrotide therapy. In all three episodes, the clinical diagnosis of SOS was associated with a significant increase in plasminogen-activator inhibitor-1 (PAI-1) that reduced with patient clinical improvement. PAI-1 warrants study as a diagnostic marker for SOS in ALL.