Analytica chimica acta · 2025
Synthesis of PbCrO4 nanorods-Ti3C2Tx MXene composites: A sensitive photoelectrochemical sensor for the detection of cysteine in human blood serum.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Lu Wenbo, Wang Yupeng, Liu Siyu, Xie Wanyu, Wei Ming, Hao Ruipeng
Аннотация
BACKGROUND: l-cysteine plays an important role in protein synthesis, osmoregulation, detoxification, nervous system function, and antioxidant process. Low levels of cysteine are associated with various diseases like cardiovascular diseases, ischemic stroke, neurological disorders, diabetes, cancer like lung and colorectal cancer, renal dysfunction-linked conditions, and vitiligo. Therefore, it is of great significance to develop a rapid and accurate method for the determination of cysteine concentration.
RESULTS: A photoelectrochemical (PEC) biosensor based on PbCrO4-MXene composites is proposed MXene for the determination of l-cysteine. The original PbCrO4 nanorods are synthesized via a redox reaction that occurred between Pb2+ and K2Cr2O7 in a weakly acidic environment using a hydrothermal approach. The PbCrO4 nanorods show outstanding PEC performance in the catalytic oxidation of l-cysteine. The introduction of Ti3C2Tx MXene nanosheets on PbCrO4 nanorods enables the formation of the local Schottky junction to efficiently improve charge transport and charge separation of PbCrO4 nanorods, achieving excellent catalytic performance. The PbCrO4-MXene composites be used as a photoelectrocatalyst for rapid and sensitive detection of l-cysteine in the human body. Compared with the traditional PEC sensor, this sensor based on PbCrO4-MXene composites can significantly improve the catalytic performance of PEC, showing a better response to l-cysteine. This PEC sensor shows a low limit of detection (LOD) of 0.23 μM for l-cysteine, and a wide linear range of 0.01-18 mM, exceeding expectations compared to previously published papers.
SIGNIFICANCE: Our PEC sensor has been successfully used for the detection of l-cysteine in human blood serum. This work provides a new inspiration for the great practical application of PEC sensors in medicine and clinical diagnosis fields.
RESULTS: A photoelectrochemical (PEC) biosensor based on PbCrO4-MXene composites is proposed MXene for the determination of l-cysteine. The original PbCrO4 nanorods are synthesized via a redox reaction that occurred between Pb2+ and K2Cr2O7 in a weakly acidic environment using a hydrothermal approach. The PbCrO4 nanorods show outstanding PEC performance in the catalytic oxidation of l-cysteine. The introduction of Ti3C2Tx MXene nanosheets on PbCrO4 nanorods enables the formation of the local Schottky junction to efficiently improve charge transport and charge separation of PbCrO4 nanorods, achieving excellent catalytic performance. The PbCrO4-MXene composites be used as a photoelectrocatalyst for rapid and sensitive detection of l-cysteine in the human body. Compared with the traditional PEC sensor, this sensor based on PbCrO4-MXene composites can significantly improve the catalytic performance of PEC, showing a better response to l-cysteine. This PEC sensor shows a low limit of detection (LOD) of 0.23 μM for l-cysteine, and a wide linear range of 0.01-18 mM, exceeding expectations compared to previously published papers.
SIGNIFICANCE: Our PEC sensor has been successfully used for the detection of l-cysteine in human blood serum. This work provides a new inspiration for the great practical application of PEC sensors in medicine and clinical diagnosis fields.