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DOI 10.1080/09273948.2017.1406529

Медицинская библиотека · Ocular immunology and inflammation · 2017

The Collaborative Ocular Tuberculosis Study (COTS)-1 Report 3: Polymerase Chain Reaction in the Diagnosis and Management of Tubercular Uveitis: Global Trends.

Agarwal Aniruddha, Agrawal Rupesh, Gunasekaran Dinesh Visva, Raje Dhananjay, Gupta Bhaskar, Aggarwal Kanika, Murthy Somasheila L, Westcott Mark, Chee Soon Phaik, McCluskey Peter, Ling Ho Su, Teoh Stephen, Cimino Luca, Biswas Jyotirmay, Narain Shishir, Agarwal Manisha, Mahendradas Padmamalini, Khairallah Moncef, Jones Nicholas, Tugal-Tutkun Ilknur, Babu Kalpana, Basu Soumayava, Carreño Ester, Lee Richard, Al-Dhibi Hassan, Bodaghi Bahram, Invernizzi Alessandro, Goldstein Debra A, Herbort Carl P, Barisani-Asenbauer Talin, González-López Julio J, Androudi Sofia, Bansal Reema, Moharana Bruttendu, Mahajan Sarakshi, Esposti Simona, Tasiopoulou Anastasia, Nadarajah Sengal, Agarwal Mamta, Abraham Sharanya, Vala Ruchi, Singh Ramandeep, Sharma Aman, Sharma Kusum, Zierhut Manfred, Kon Onn Min, Cunningham Emmett, Nguyen Quan Dong, Pavesio Carlos, Gupta Vishali

СтатьяМногоцентровое исследованиеПеревод пока не подготовлен

Аннотация

Purpose: To analyze the role of polymerase chain reaction (PCR) of ocular fluids in management of tubercular (TB) anterior, intermediate, posterior, and panuveitis.

Methods

In Collaborative Ocular Tuberculosis Study (COTS)-1 (25 centers, n = 962), patients with TB-related uveitis were included. 59 patients undergoing PCR of intraocular fluids (18 females; 53 Asian Indians) were included.

Results

59 (6.13%) of COTS-1 underwent PCR analysis. PCR was positive for Mycobacterium TB in 33 patients (23 males; all Asian Indians). 26 patients were PCR negative (18 males). Eight patients with negative PCR had systemic TB. Anti-TB therapy was given in 18 negative and 31 PCR cases. At 1-year follow-up, five patients with positive PCR (15.15%) and three with negative PCR (11.54%) had persistence/worsening of inflammation.

Conclusions

Data from COTS-1 suggest that PCR is not commonly done for diagnosing intraocular TB and positive/negative results may not influence management or treatment outcomes in the real world scenario.

Для цитирования: Agarwal Aniruddha, Agrawal Rupesh, Gunasekaran Dinesh Visva, Raje Dhananjay, Gupta Bhaskar, Aggarwal Kanika, Murthy Somasheila L, Westcott Mark, Chee Soon Phaik, McCluskey Peter, Ling Ho Su, Teoh Stephen, Cimino Luca, Biswas Jyotirmay, Narain Shishir, Agarwal Manisha, Mahendradas Padmamalini, Khairallah Moncef, Jones Nicholas, Tugal-Tutkun Ilknur, Babu Kalpana, Basu Soumayava, Carreño Ester, Lee Richard, Al-Dhibi Hassan, Bodaghi Bahram, Invernizzi Alessandro, Goldstein Debra A, Herbort Carl P, Barisani-Asenbauer Talin, González-López Julio J, Androudi Sofia, Bansal Reema, Moharana Bruttendu, Mahajan Sarakshi, Esposti Simona, Tasiopoulou Anastasia, Nadarajah Sengal, Agarwal Mamta, Abraham Sharanya, Vala Ruchi, Singh Ramandeep, Sharma Aman, Sharma Kusum, Zierhut Manfred, Kon Onn Min, Cunningham Emmett, Nguyen Quan Dong, Pavesio Carlos, Gupta Vishali. The Collaborative Ocular Tuberculosis Study (COTS)-1 Report 3: Polymerase Chain Reaction in the Diagnosis and Management of Tubercular Uveitis: Global Trends.. Ocular immunology and inflammation. 2017. DOI: 10.1080/09273948.2017.1406529.

Предметные рубрики MeSH

AdolescentAdultAgedAntitubercular AgentsAqueous HumorChildDNA, BacterialEye Infections, BacterialFemaleFollow-Up StudiesHumansMaleMiddle AgedMycobacterium tuberculosisPolymerase Chain ReactionRetrospective StudiesTuberculosis, OcularUveitisYoung Adult
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