Alzheimer's & dementia : the journal of the Alzheimer's Association · 2009
Cerebral blood flow in ischemic vascular dementia and Alzheimer's disease, measured by arterial spin-labeling magnetic resonance imaging.
Сравнительное исследованиеСтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Schuff Norbert, Matsumoto Shinji, Kmiecik Joseph, Studholme Colin, Du Antao, Ezekiel Frank, Miller Bruce L, Kramer Joel H, Jagust William J, Chui Helen C, Weiner Michael W
Аннотация
BACKGROUND: Our objectives were to compare the effects of subcortical ischemic vascular dementia (SIVD) and Alzheimer's disease (AD) on cerebral blood flow (CBF), and then to analyze the relationship between CBF and subcortical vascular disease, measured as volume of white-matter lesions (WMLs).
METHODS: Eight mildly demented patients with SIVD (mean +/- SD; aged 77 +/- 8 years; Mini-Mental State Examination score 26 +/- 3 years) and 14 patients with AD were compared with 18 cognitively normal elderly subjects. All subjects had CBF measured using arterial spin-labeling magnetic resonance imaging, and brain volumes were assessed using structural magnetic resonance imaging.
RESULTS: AD and SIVD showed marked CBF reductions in the frontal (P = 0.001) and parietal (P = 0.001) cortices. In SIVD, increased subcortical WMLs were associated with reduced CBF in the frontal cortex (P = 0.04), in addition to cortical atrophy (frontal, P = 0.05; parietal, P = 0.03).
CONCLUSIONS: Subcortical vascular disease is associated with reduced CBF in the cortex, irrespective of brain atrophy.
METHODS: Eight mildly demented patients with SIVD (mean +/- SD; aged 77 +/- 8 years; Mini-Mental State Examination score 26 +/- 3 years) and 14 patients with AD were compared with 18 cognitively normal elderly subjects. All subjects had CBF measured using arterial spin-labeling magnetic resonance imaging, and brain volumes were assessed using structural magnetic resonance imaging.
RESULTS: AD and SIVD showed marked CBF reductions in the frontal (P = 0.001) and parietal (P = 0.001) cortices. In SIVD, increased subcortical WMLs were associated with reduced CBF in the frontal cortex (P = 0.04), in addition to cortical atrophy (frontal, P = 0.05; parietal, P = 0.03).
CONCLUSIONS: Subcortical vascular disease is associated with reduced CBF in the cortex, irrespective of brain atrophy.
Предметные рубрики MeSH
AgedAged, 80 and overAlzheimer DiseaseAtrophyBrainBrain IschemiaBrain MappingCerebral ArteriesCerebrovascular CirculationDementia, VascularDisease ProgressionFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleNerve Fibers, MyelinatedPredictive Value of TestsSensitivity and SpecificitySeverity of Illness IndexSpin Labels