The ongoing antibiotic resistance and carbapenemase encoding genotypes surveillance. The first quarter report of the INVIFAR network for 2024.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Colín-Castro Claudia Adriana, López-Jácome Luis Esaú, Rodríguez-García María José, Garibaldi-Rojas Melissa, Rojas-Larios Fabián, Vázquez-Larios María Del Rosario, Quintana-Ponce Sandra, Franco-Cendejas Rafael, Gómez-Quiróz Adolfo, Rodríguez-Zulueta Patricia, Rosado-Espinosa Thalia, Quintanilla-Cazares Luis Javier, Velázquez-Acosta Consuelo, Sandoval-Villaseñor Pablo Hernan, Mena-Ramírez Juan Pablo, Choy-Chang Elena Victoria, González-Lara María Fernanda, Martínez-Guerra Bernardo A, Bolado-Martínez Enrique, Aviles-Benítez Laura Karina, Feliciano-Guzmán José Manuel, Couoh-May Carlos Antonio, Pérez-Vicelis Talia, Silva-Gamiño Aldo Rafael, Rivera-Garay Luis Raúl, Navarro-Vargas Norberta Vianey, Gutiérrez-Brito Maricruz, Adame-Álvarez César, Suárez-Moreno Sandra María, Pérez-Vega Bertha Alicia, López-Moreno Laura Isabel, Jacobo-Baca Guillermo, Galindo-Méndez Mario, Ballesteros-Silva María Bertha, Vázquez-Narvaez Elda Gabriela, Barlandas-Rendón Nicolás Rogelio Eric, Rodríguez-Balderas Dora Elia, Castañeda-Duarte Juan de Dios, Padilla-Ibarra Cecilia, Peralta-Peñúñuri Víctor Hugo, López-Vázquez Alma Denia, Santiago-Calderón María Asunción, Cecilia Valtierra Ángela, González-Melgoza Paulina Fabiola, Medina-Navarro Luis Gerardo, Mireles-Dávalos Christian Daniel, De-la-Cruz-Hernández Ibis, Huirache-Villalobos Guadalupe Soledad, Aguilar-Trejo Ernesto Mario, López-Álvarez María Del Rocío, Garza-González Elvira
Аннотация
METHODS: Databases of identification and susceptibility results collected from January 1 to March 31, 2024, from forty-one centers were gathered and analyzed using the WHONET software. Some relevant gram-negatives and gram-positives, which were isolated from relevant clinical specimens were included. Isolates were stratified by patient´s age, clinical specimens, and site of attention, and were classified as multidrug-resistant (MDR). Clinical isolates were collected from January 1 to June 30 and were genotyped for carbapenemase-encoding genes by a polymerase chain reaction test.
RESULTS: In total, 8 708 strains were included. Escherichia coli had a higher resistance to carbapenems (p < 0.05) in the 0-17 years group and Klebsiella pneumoniae (p = 0.017), Pseudomonas aeruginosa, and Acinetobacter baumannii (p < 0.05) in the 18-59 years group. P. aeruginosa had higher resistance to ceftazidime-avibactam, ceftolozane-tazobactam, cefepime, and imipenem (p < 0.05) in the 18-59 years group. K. pneumoniae had the highest resistance to carbapenems (p < 0.05) and cefepime (p < 0.001) in clinical isolates recovered from blood. For P. aeruginosa, the highest resistance to cefepime (p = 0.012) and ceftazidime (p < 0.018) was seen in isolates from urine. For Staphylococcus aureus, a higher resistance was observed for cefoxitin in lower respiratory tract specimens (p < 0.05). E. coli had the highest resistance to carbapenems (p < 0.01), and P. aeruginosa for ceftazidime (p = 0.005), cefepime (p = 0.003), piperacillin-tazobactam (p = <0.01), IPM (p = 0.006), and meropenem (p = <0.01) in clinical isolates recovered from patients in the intensive care unit (ICU). For K. pneumoniae, the highest resistance to ertapenem was observed in clinical isolates from the ICU area (p < 0.035). Finally, 67.9% of A. baumannii and 53.8% of E. coli strains were Multidrug-resistant. Candida albicans isolated from blood had susceptibility to caspofungin 100% and 90.2% for voriconazole. Regarding E. coli non-susceptible to meropenem, 16 (59.2%) were carriers of blaNDM, and the blaKPC gene was detected in 2 (40%) strains of K. pneumoniae. In conclusion, carbapenem resistance was higher for E. coli in the 0-17 years group and for K. pneumoniae, P. aeruginosa, and A. baumannii in the 18-59 years group. K. pneumoniae has the highest resistance to carbapenems in blood isolates and the ICU area. E. coli and P. aeruginosa had the highest carbapenem resistance in the intensive care unit. A high multidrug resistance was observed for A. baumannii and E. coli strains. A high susceptibility to caspofungin and voriconazole was observed for Candida albicans collected from blood.