[Social-epidemiologic and economic effect of implementation of a program of vaccination of young children in Russia against pneumococcal infection].

Literature data on the evaluation of clinical-epidemiologic and social effectiveness of implementation of programs of vaccination against pneumococcal infection in various countries are presented in the review. A prognosis of pharmacoeconomic effectiveness of a universal vaccination of children at the first years of life during realization of program in Russia, where more than 3000 children yearly suffer from pneumococcal bacteremia, around 39 000 have pneumococcal pneumonia and more than 700 000--pneumococcal otitis is given. The frequency of lethal outcomes from pneumococcal meningitis in Russia is 20-40% and exceeds similar parameters of meningitis of other etiology. Cost for the state from the therapy ofpneumococcal infections is no less than 30 646 milliards of RUR (Russian ruble) based on 2009 calculations. In Russia 5 years after an implementation of yearly mass immunization in children aged from 2 months against pneumococcal infection an overall economic effect of the program of mass vaccination would be 39.19 milliards of RUR. With direct costs reducing by 19.69 milliards of RUR, and indirect costs (temporarily disability allowance payment, reduction of losses of gross domestic product)--by 37.4 milliards of RUR.