The American journal of clinical nutrition · 2025
Dietary patterns and risk of Alzheimer's disease and related dementias across 5 racial and ethnic groups in the Multiethnic Cohort Study.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Park Song-Yi, Setiawan Veronica Wendy, Crimmins Eileen M, White Lon R, Haiman Christopher A, Wilkens Lynne R, Le Marchand Loïc, Lim Unhee
Аннотация
BACKGROUND: Healthier dietary patterns have been linked to a lower risk of dementia, but data from diverse racial and ethnic populations are limited, particularly to support dietary improvement in older adults.
OBJECTIVES: We examined dietary patterns in relation to late-onset Alzheimer's disease and related dementia (ADRD) risk across 5 racial and ethnic groups in the Multiethnic Cohort Study.
METHODS: Participants were scored for 4 predefined dietary pattern indices based on their food frequency questionnaire responses at baseline (45-75 y) and at a 10-y follow-up: the alternate Mediterranean diet (aMED), the Dietary Approaches to Stop Hypertension (DASH), the Healthy Eating Index-2015 (HEI-2015), and the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet. Associations between dietary patterns and ADRD were examined using Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).
RESULTS: Among 92,849 participants with 21,478 cases, higher baseline scores of the 4 dietary patterns were associated with 4%‒9% lower ADRD risk (for aMED, HR 0.91, 95% CI: 0.87, 0.95; for DASH, HR 0.96, 95% CI: 0.92, 1.01; for HEI-2015, HR 0.94, 95% CI: 0.90, 0.98; for MIND, HR 0.91, 95% CI: 0.87, 0.96) over the follow-up, with stronger associations observed in African American, Latino, and White participants than in Japanese American and Native Hawaiian participants. Dietary improvement over 10 y was associated with 11%‒25% lower risk across the 4 indices in a subset of 45,065 participants with 8360 cases, with similar racial and ethnic differences as observed for baseline diet, but consistently for younger (<60 y at baseline) and older age groups.
CONCLUSIONS: Healthy dietary patterns in mid- to late-life and improvement in older age were associated with a reduced risk of ADRD in a diverse population. The racial and ethnic heterogeneity in the relationships observed warrants further study.
OBJECTIVES: We examined dietary patterns in relation to late-onset Alzheimer's disease and related dementia (ADRD) risk across 5 racial and ethnic groups in the Multiethnic Cohort Study.
METHODS: Participants were scored for 4 predefined dietary pattern indices based on their food frequency questionnaire responses at baseline (45-75 y) and at a 10-y follow-up: the alternate Mediterranean diet (aMED), the Dietary Approaches to Stop Hypertension (DASH), the Healthy Eating Index-2015 (HEI-2015), and the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet. Associations between dietary patterns and ADRD were examined using Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).
RESULTS: Among 92,849 participants with 21,478 cases, higher baseline scores of the 4 dietary patterns were associated with 4%‒9% lower ADRD risk (for aMED, HR 0.91, 95% CI: 0.87, 0.95; for DASH, HR 0.96, 95% CI: 0.92, 1.01; for HEI-2015, HR 0.94, 95% CI: 0.90, 0.98; for MIND, HR 0.91, 95% CI: 0.87, 0.96) over the follow-up, with stronger associations observed in African American, Latino, and White participants than in Japanese American and Native Hawaiian participants. Dietary improvement over 10 y was associated with 11%‒25% lower risk across the 4 indices in a subset of 45,065 participants with 8360 cases, with similar racial and ethnic differences as observed for baseline diet, but consistently for younger (<60 y at baseline) and older age groups.
CONCLUSIONS: Healthy dietary patterns in mid- to late-life and improvement in older age were associated with a reduced risk of ADRD in a diverse population. The racial and ethnic heterogeneity in the relationships observed warrants further study.