Platelet count at diagnosis predicts survival in children with acute lymphoblastic leukemia.
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Olivares-Villalpando Víctor H, Peñaloza-González José G, Velázquez-Aviña Martha M, Sierra-Zamora Dania A, Mayo-Velasco Analicia, Sandoval-Ruiz Miguel E, Cabrera-Enríquez Andrea A, Vargas-De-León Cruz, Romero-Reyes Eimy M, Rosales-Islas Katherine K, Valladares-Ocampo Mariana, Olivares-Vázquez María F, Pineda-Cortes Stephanie P, Ramos-Caulleres Sebastian S, Pérez-Ruiz Ernesto R, Reyes-Murra Miriam A, Cruz-García Carolina F, Valdez-Alvarez Anaid, Maldonado-Hernández Luisa M, Gálvez-Tapia Susan A, Quevedo-Rangel María J, Segura-Zavala Jorge F, Vélez-Uribe Francisco J, Alonso-Bringas Alma P, Braverman-Poyastro Alan, Sámano-Temores Aranza, Rueda-Meneses Adolfo, Sotelo-López José C, Moreno-Yllescas Isis Y
Аннотация
OBJECTIVE: To associate the initial platelet count with survival in pediatric patients with acute lymphoblastic leukemia.
MATERIAL AND METHODS: The survival of two groups of pediatric patients with acute lymphoblastic leukemia was compared, divided considering the platelet count that each patient had at the time of the onset of leukemia; a platelet count of 50 × 109/L was chosen as the cut-off point for the division into groups. Kaplan-Meier survival curves and Cox regression were used for the analysis.
RESULTS: A platelet count > 50 × 109/L predicted a better prognosis in children with acute lymphoblastic leukemia, with p = 0.002 in the bivariate analysis (Kaplan-Meier log rank). The multivariate analysis with Cox regression identifies the initial platelet count as a predictor of overall survival, with p = 0.025 (HR: 1.42; 95% CI: 1.15-4.47)).
CONCLUSIONS: The platelet count at diagnosis is directly associated with survival independently of the other prognostic factors described.