Head & neck · 2016
Impaired vocal cord mobility in T2N0 glottic carcinoma: Suboptimal local control with Radiation alone.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Bhateja Priyanka, Ward Matthew C, Hunter Grant H, Greskovich John F, Reddy Chandana A, Nwizu Tobenna I, Lamarre Eric, Burkey Brian B, Adelstein David J, Koyfman Shlomo A
Аннотация
BACKGROUND: T2 glottic cancer with impaired vocal cord mobility (T2b) is known to have higher local failure rates when compared with T2 cancers without impaired cord mobility (T2a) treated with radiotherapy (RT) alone.
METHODS: In this retrospective review, we identified and compared the local control rates of 3 groups: T2aN0 treated with RT; T2bN0 treated with RT; and T2b-3N0-2 treated with chemoradiotherapy (CRT).
RESULTS: The 3-year local control rate was 95.1% for T2aN0, 73.2% for T2bN0 treated with RT, and 91.5% for the CRT group (p = .01). On univariate analysis, T2bN0 disease versus T2aN0 treated with RT alone (p = .03) was significantly associated with inferior local control.
CONCLUSION: Patients with glottic cancer with impaired vocal cord mobility (T2b) have a high rate of local failure with RT alone. The addition of concurrent chemotherapy should be considered for patients highly motivated toward larynx preservation and willing to accept the potential toxicity. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1832-1836, 2016.
METHODS: In this retrospective review, we identified and compared the local control rates of 3 groups: T2aN0 treated with RT; T2bN0 treated with RT; and T2b-3N0-2 treated with chemoradiotherapy (CRT).
RESULTS: The 3-year local control rate was 95.1% for T2aN0, 73.2% for T2bN0 treated with RT, and 91.5% for the CRT group (p = .01). On univariate analysis, T2bN0 disease versus T2aN0 treated with RT alone (p = .03) was significantly associated with inferior local control.
CONCLUSION: Patients with glottic cancer with impaired vocal cord mobility (T2b) have a high rate of local failure with RT alone. The addition of concurrent chemotherapy should be considered for patients highly motivated toward larynx preservation and willing to accept the potential toxicity. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1832-1836, 2016.
Предметные рубрики MeSH
AdultAgedAged, 80 and overAnalysis of VarianceChemoradiotherapyDatabases, FactualDisease-Free SurvivalFemaleGlottisHumansKaplan-Meier EstimateLaryngeal NeoplasmsMaleMiddle AgedPredictive Value of TestsPrognosisProportional Hazards ModelsRadiotherapy DosageRadiotherapy, Intensity-ModulatedRetrospective StudiesRisk AssessmentSurvival AnalysisTreatment OutcomeVocal Cord Paralysis