Respiratory medicine · 2026
Bridging the global survival gap in cystic fibrosis: Evidence from a 30-year longitudinal Mexican cohort.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Reyes-Apodaca Magali, Vázquez-Frias Rodrigo, Núñez-Barrera Isela, Lezana-Fernández José Luis
Аннотация
BACKGROUND: Survival in cystic fibrosis (CF) has improved markedly in high-income countries over recent decades; however, important disparities persist across regions. Long-term data describing survival patterns and their determinants in middle-income settings remain limited. The aim of this study was to estimate survival in Mexican patients with CF over three decades and to explore the clinical and health-system factors associated with mortality.
METHODS: we conducted a retrospective longitudinal cohort study including patients with a confirmed diagnosis of CF followed at a national tertiary referral center in Mexico between 1990 and 2020. Survival was estimated using the Kaplan-Meier method. Potential predictors of mortality were evaluated through univariate analyses and multivariable Cox proportional hazards regression. Temporal changes in demographic, clinical, nutritional, microbiological, and treatment-related characteristics were also examined.
RESULTS: a total of 341 patients were included. Median estimated survival was 20 years (95% CI 17.3-23.0) and appeared to improve over time. In multivariable analyses, early detection of P. aeruginosa ≤7 years, malnutrition, and reduced pulmonary function were associated with increased mortality, whereas access to complete standard CF treatment was associated with lower mortality.
CONCLUSIONS: survival among Mexican patients with CF has improved over the past three decades but continues to lag that reported in high-income countries. The findings suggest that long-term outcomes are strongly influenced by modifiable clinical factors and access to comprehensive care. Strengthening multidisciplinary management, ensuring equitable treatment availability, and developing national CF registries may be essential steps toward reducing avoidable mortality and narrowing global survival disparities.
METHODS: we conducted a retrospective longitudinal cohort study including patients with a confirmed diagnosis of CF followed at a national tertiary referral center in Mexico between 1990 and 2020. Survival was estimated using the Kaplan-Meier method. Potential predictors of mortality were evaluated through univariate analyses and multivariable Cox proportional hazards regression. Temporal changes in demographic, clinical, nutritional, microbiological, and treatment-related characteristics were also examined.
RESULTS: a total of 341 patients were included. Median estimated survival was 20 years (95% CI 17.3-23.0) and appeared to improve over time. In multivariable analyses, early detection of P. aeruginosa ≤7 years, malnutrition, and reduced pulmonary function were associated with increased mortality, whereas access to complete standard CF treatment was associated with lower mortality.
CONCLUSIONS: survival among Mexican patients with CF has improved over the past three decades but continues to lag that reported in high-income countries. The findings suggest that long-term outcomes are strongly influenced by modifiable clinical factors and access to comprehensive care. Strengthening multidisciplinary management, ensuring equitable treatment availability, and developing national CF registries may be essential steps toward reducing avoidable mortality and narrowing global survival disparities.