Journal of Alzheimer's disease : JAD · 2025

Associations of lifestyle factors with amyloid pathology in persons without dementia.

СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен

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Oomens Julie E, Vos Stephanie Jb, Maserejian Nancy N, Boada Mercè, Didic Mira, Engelborghs Sebastiaan, Fladby Tormod, van der Flier Wiesje M, Frisoni Giovanni B, Fröhlich Lutz, Gill Kiran Dip, Grimmer Timo, Hort Jakub, Itoh Yoshiaki, Iwatsubo Takeshi, Klimkowicz-Mrowiec Aleksandra, Landau Susan M, Lee Dong Young, Lleó Alberto, Martinez-Lage Pablo, de Mendonça Alexandre, Meyer Philipp T, Parchi Piero, Pardini Matteo, Parnetti Lucilla, Popp Julius, Rami Lorena, Reiman Eric M, Rinne Juha O, Rodrigue Karen M, Sánchez-Juan Pascual, Santana Isabel, Scarmeas Nikolaos, Scheltens Philip, Skoog Ingmar, Sperling Reisa A, Stern Yaakov, Villeneuve Sylvia, Waldemar Gunhild, Wiltfang Jens, Zetterberg Henrik, Alcolea Daniel, Allegri Ricardo F, Altomare Daniele, Bateman Randall J, Baiardi Simone, Baldeiras Ines, Blennow Kaj, Braber Anouk den, van Buchem Mark A, Byun Min Soo, Cerman Jiří, Chen Kewei, Chipi Elena, Day Gregory S, Drzezga Alexander, Ekblad Laura L, Förster Stefan, Fortea Juan, Freund-Levi Yvonne, Frings Lars, Guedj Eric, Habeck Christian G, Handels Ron, Hausner Lucrezia, Hellwig Sabine, Jiménez-Bonilla Julio F, Juaristi Ane Iriondo, Kandimalla Ramesh, Kern Silke, Bordewick Kirsebom Bjørn-Eivind S, Kornhuber Johannes, Legdeur Nienke, Levin Johannes, Maier Wolfgang, Marquié Marta, Minatani Shinobu, Morbelli Silvia Daniela, Mroczko Barbara, Ntanasi Eva, de Oliveira Catarina Resende, Orellana Adelina, Peters Oliver, Prabhakar Sudesh, Ramakers Inez H, Rodríguez-Rodriguez Eloy, Ruiz Agustín, Rüther Eckart, Sakhardande Jayant, Selnes Per, Silva Dina, Soininen Hilkka, Spiru Luiza, Takeda Akitoshi, Teunissen Charlotte E, Tijms Betty M, Vermunt Lisa, Wallin Åsa K, Wiels Wietse, Yannakoulia Mary, Yi Dahyun, Zettergren Anna, Alzheimer's Disease Neuroimaging Initiative (ADNI), A4 Study group, Dominantly Inherited Alzheimer Network (DIAN), European Prevention of Alzheimer's Dementia (EPAD) consortium, Fundació ACE Healthy Brain Initiative (FACEHBI), Japan Alzheimer's Disease Neuroimaging Initiative (J-ADNI), Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease (KBASE), Presymptomatic Evaluation of Experimental or Novel Treatments for Alzheimer's Disease (PREVENT-AD) research group, Ossenkoppele Rik, Verhey Frans Rj, Visser Pieter Jelle, Jansen Willemijn J

Аннотация

BackgroundThe association between lifestyle factors and Alzheimer's disease (AD) pathophysiology remains incompletely understood.ObjectiveThe aim of this study was to assess the association of alcohol consumption, smoking behavior, sleep quality and physical, cognitive, and social activity with cerebral amyloid pathology.MethodsFor this cross-sectional study, we selected participants from the Amyloid Biomarker Study data pooling initiative. We used generalized estimating equations to assess associations of dichotomized lifestyle measures with amyloid pathology.ResultsWe included 9171 participants with normal cognition (NC) and 2555 participants with mild cognitive impairment (MCI) from the Amyloid Biomarker Study. Of participants with NC, 58% were women, 34% were APOE ε4 carrier, and 27% had amyloid pathology. Of participants with MCI, 48% were women, 47% were APOE ε4 carrier, and 57% had amyloid pathology. In NC, cognitively active participants were less likely to have amyloid pathology (OR = 0.77, 95%CI 0.66-0.89, p < 0.001). In MCI, participants who had ever smoked or had sleep problems were less likely to have amyloid pathology (OR = 0.85, 95%CI 0.73-0.99, p = 0.029; OR = 0.62, 95%CI 0.45-0.86, p = 0.004).ConclusionsIn NC, cognitive activity was associated with a lower frequency of amyloid pathology. In MCI, favorable lifestyle behaviors were not associated with a lower frequency of amyloid pathology. The results of the current study contribute to the broader evidence base on lifestyle and AD by further characterizing the role of lifestyle behaviors in AD pathology across different clinical stages.

Предметные рубрики MeSH

Humans Female Male Aged Life Style Cross-Sectional Studies Cognitive Dysfunction Aged, 80 and over Alcohol Drinking Smoking Middle Aged Amyloid Apolipoprotein E4 Dementia

Associations of lifestyle factors with amyloid pathology in persons without dementia.

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Аннотация

Предметные рубрики MeSH