Viruses · 2022
Clearance of Persistent SARS-CoV-2 RNA Detection in a NFκB-Deficient Patient in Association with the Ingestion of Human Breast Milk: A Case Report.
Клинический случайПоддержка исследования: вне правительства СШАПоддержка NIH: внешняя программаСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Sabino Janine S, Amorim Mariene R, de Souza William M, Marega Lia F, Mofatto Luciana S, Toledo-Teixeira Daniel A, Forato Julia, Stabeli Rodrigo G, Costa Maria Laura, Spilki Fernando R, Sabino Ester C, Faria Nuno R, Benites Bruno D, Addas-Carvalho Marcelo, Stucchi Raquel S B, Vasconcelos Dewton M, Weaver Scott C, Granja Fabiana, Proenca-Modena José Luiz, Vilela Maria Marluce Dos S
Аннотация
Currently, there are no evidence-based treatment options for long COVID-19, and it is known that SARS-CoV-2 can persist in part of the infected patients, especially those with immunosuppression. Since there is a robust secretion of SARS-CoV-2-specific highly-neutralizing IgA antibodies in breast milk, and because this immunoglobulin plays an essential role against respiratory virus infection in mucosa cells, being, in addition, more potent in neutralizing SARS-CoV-2 than IgG, here we report the clinical course of an NFκB-deficient patient chronically infected with the SARS-CoV-2 Gamma variant, who, after a non-full effective treatment with plasma infusion, received breast milk from a vaccinated mother by oral route as treatment for COVID-19. After such treatment, the symptoms improved, and the patient was systematically tested negative for SARS-CoV-2. Thus, we hypothesize that IgA and IgG secreted antibodies present in breast milk could be useful to treat persistent SARS-CoV-2 infection in immunodeficient patients.